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Research ArticleOriginal Article
Open Access

COMTVal158Met polymorphism is associated with ecstasy (MDMA)-induced psychotic symptoms in the Turkish population

Hasan Mervan Aytac, Yasemin Oyaci, Pinar Cetinay Aydin, Mustafa Pehlivan and Sacide Pehlivan
Neurosciences Journal January 2022, 27 (1) 24-30; DOI: https://doi.org/10.17712/nsj.2022.1.20210045
Hasan Mervan Aytac
From the Department of Psychiatry (Aytac), Basaksehir Cam and Sakura City Hospital; Department of Medical Biology (Oyaci, Pehlivan), Istanbul Faculty of Medicine, Istanbul University, and from the Department of Psychiatry (Cetinay Aydin), Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Psychiatry Clinic, University of Health Sciences, Istanbul, and from the Department of Hematology (Pehlivan), Gaziantep University, Faculty of Medicine, Gaziantep, Turkey
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  • For correspondence: [email protected]
Yasemin Oyaci
From the Department of Psychiatry (Aytac), Basaksehir Cam and Sakura City Hospital; Department of Medical Biology (Oyaci, Pehlivan), Istanbul Faculty of Medicine, Istanbul University, and from the Department of Psychiatry (Cetinay Aydin), Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Psychiatry Clinic, University of Health Sciences, Istanbul, and from the Department of Hematology (Pehlivan), Gaziantep University, Faculty of Medicine, Gaziantep, Turkey
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Pinar Cetinay Aydin
From the Department of Psychiatry (Aytac), Basaksehir Cam and Sakura City Hospital; Department of Medical Biology (Oyaci, Pehlivan), Istanbul Faculty of Medicine, Istanbul University, and from the Department of Psychiatry (Cetinay Aydin), Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Psychiatry Clinic, University of Health Sciences, Istanbul, and from the Department of Hematology (Pehlivan), Gaziantep University, Faculty of Medicine, Gaziantep, Turkey
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Mustafa Pehlivan
From the Department of Psychiatry (Aytac), Basaksehir Cam and Sakura City Hospital; Department of Medical Biology (Oyaci, Pehlivan), Istanbul Faculty of Medicine, Istanbul University, and from the Department of Psychiatry (Cetinay Aydin), Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Psychiatry Clinic, University of Health Sciences, Istanbul, and from the Department of Hematology (Pehlivan), Gaziantep University, Faculty of Medicine, Gaziantep, Turkey
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Sacide Pehlivan
From the Department of Psychiatry (Aytac), Basaksehir Cam and Sakura City Hospital; Department of Medical Biology (Oyaci, Pehlivan), Istanbul Faculty of Medicine, Istanbul University, and from the Department of Psychiatry (Cetinay Aydin), Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery, Psychiatry Clinic, University of Health Sciences, Istanbul, and from the Department of Hematology (Pehlivan), Gaziantep University, Faculty of Medicine, Gaziantep, Turkey
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    Table 1

    -Sociodemographic characteristics and clinical parameters of patients.

    Ecstasy (MDMA) use disorder
    (Years)Mean±SD
    Age27.40±6.96
    Age of onset16.84±4.21
    Duration of disorder11.29±7.46
    Sexn (%)
     Female0 (0)
     Male82 (100)
    Education
     Literate4 (4.9)
     Primary School18 (22.0)
     Secondary School40 (48.8)
     High School19 (23.2)
     University1 (1.2)
    COMT Val158Met
     Met/Met12 (14.6)
     Val/Met34 (41.5)
     Val/Val36 (43.9)
    Tobacco - No1 (1.2)
    Usage - Yes81 (98.8)
    Alcohol - No50 (61)
    Usage - Yes32 (39)
    Psychotic - No37 (45.1)
    Symptom - Yes45 (54.9)
    Attempted - No56 (68.3)
    Suicide - Yes26 (31.7)
    • SD - standard deviation, MDMA - 3,4-Methylenedioxymethamphetamine, COMT - Catechol-O-methyltransferase

    • View popup
    Table 2

    - Comparison of genotype distributions of COMT Val158Met polymorphism in patients with the control.

    GenotypeMDMAControlOR95% CIP-value
    COMTVal158Metn=a (%)n=95 (%)   
     Met/Met12 (14.6)30 (31.6)2.692*1.272-5.698*0.008*
     Val/Met34 (41.5)32 (33.7)0.717*0.389-1.322*0.286*
     Val/Val36 (43.9)33 (34.7)0.680*0.371-1.248*0.212*
    Allele
     Met58 (35.4)92 (48.4)   
     Val106 (64.6)98 (51.6)1.716*1.118-2.633*0.013*
    • MDMA, 3,4-Methylenedioxymethamphetamine; an= 82; OR, odds ratio; CI, confidence interval; *Pearson chi-square

    • View popup
    Table 3

    - Comparison of genotype distributions of COMT Val158Met in patients due to psychotic symptoms.

    Psychotic Symptoms/GenotypeYesNoOR95% CIP-value
    COMTVal158Metn= a (%)n=37 (%)   
    Met/Met5 (11.1)7 (18.9)0.536*0.155-1.854*0.320*
    Val/Met25 (55.6)9 (24.3)3.889*1.498-10.094*0.004*
    Val/Val15 (33.3)21 (56.8)2.625*1.069-6.446*0.033*
    Allele
    Met35 (38.9)23 (31.1)   
    Val55 (61.1)51 (68.9)1.411*0.737-2.702*0.298*
    • COMT, Catechol-O-methyltransferase; an= 45; OR, odds ratio; CI, confidence interval; *Pearson chi-square

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COMTVal158Met polymorphism is associated with ecstasy (MDMA)-induced psychotic symptoms in the Turkish population
Hasan Mervan Aytac, Yasemin Oyaci, Pinar Cetinay Aydin, Mustafa Pehlivan, Sacide Pehlivan
Neurosciences Journal Jan 2022, 27 (1) 24-30; DOI: 10.17712/nsj.2022.1.20210045

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COMTVal158Met polymorphism is associated with ecstasy (MDMA)-induced psychotic symptoms in the Turkish population
Hasan Mervan Aytac, Yasemin Oyaci, Pinar Cetinay Aydin, Mustafa Pehlivan, Sacide Pehlivan
Neurosciences Journal Jan 2022, 27 (1) 24-30; DOI: 10.17712/nsj.2022.1.20210045
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