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Research ArticleOriginal Article
Open Access

An evaluation of neuropsychiatric manifestations in systemic lupus erythematosus patients in Saudi Arabia and their associated factors

Yousef M. Alammari, Mahmoud A. Gaddoury, Abdullah A. Alaryni, Abdullah H. Alghamdi, Sara A. Alharbi, Reem A. Almohaini, Lena S. Alsaleem, Lujain H. Allowaihiq and Maha H. Alrashid
Neurosciences Journal July 2023, 28 (3) 177-183; DOI: https://doi.org/10.17712/nsj.2023.3.20220127
Yousef M. Alammari
From the Department of Internal Medicine (Alammari, Alaryni, Alghamdi, Alharbi, Almohaini, Alsaleem, Allowaihiq, Alrashid), College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, and from Department of Community Medicine (Gaddoury), Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia
MBBS, MSc
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  • ORCID record for Yousef M. Alammari
  • For correspondence: [email protected]
Mahmoud A. Gaddoury
From the Department of Internal Medicine (Alammari, Alaryni, Alghamdi, Alharbi, Almohaini, Alsaleem, Allowaihiq, Alrashid), College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, and from Department of Community Medicine (Gaddoury), Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia
MBBS, MPH, DrPH
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Abdullah A. Alaryni
From the Department of Internal Medicine (Alammari, Alaryni, Alghamdi, Alharbi, Almohaini, Alsaleem, Allowaihiq, Alrashid), College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, and from Department of Community Medicine (Gaddoury), Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia
MBBS
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Abdullah H. Alghamdi
From the Department of Internal Medicine (Alammari, Alaryni, Alghamdi, Alharbi, Almohaini, Alsaleem, Allowaihiq, Alrashid), College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, and from Department of Community Medicine (Gaddoury), Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia
MBBS
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Sara A. Alharbi
From the Department of Internal Medicine (Alammari, Alaryni, Alghamdi, Alharbi, Almohaini, Alsaleem, Allowaihiq, Alrashid), College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, and from Department of Community Medicine (Gaddoury), Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia
MBBS
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Reem A. Almohaini
From the Department of Internal Medicine (Alammari, Alaryni, Alghamdi, Alharbi, Almohaini, Alsaleem, Allowaihiq, Alrashid), College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, and from Department of Community Medicine (Gaddoury), Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia
MBBS
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Lena S. Alsaleem
From the Department of Internal Medicine (Alammari, Alaryni, Alghamdi, Alharbi, Almohaini, Alsaleem, Allowaihiq, Alrashid), College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, and from Department of Community Medicine (Gaddoury), Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia
MBBS
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Lujain H. Allowaihiq
From the Department of Internal Medicine (Alammari, Alaryni, Alghamdi, Alharbi, Almohaini, Alsaleem, Allowaihiq, Alrashid), College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, and from Department of Community Medicine (Gaddoury), Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia
MBBS
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Maha H. Alrashid
From the Department of Internal Medicine (Alammari, Alaryni, Alghamdi, Alharbi, Almohaini, Alsaleem, Allowaihiq, Alrashid), College of Medicine, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, and from Department of Community Medicine (Gaddoury), Faculty of Medicine, King Abdulaziz University (KAU), Jeddah, Kingdom of Saudi Arabia
MBBS
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  • Figure 1
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    Figure 1

    - Pattern of NPSLE manifestations in SLE patients in Saudi Arabia 2021.

Tables

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    Table 1

    - Socio-demographic characteristics of patients diagnosed with SLE (n=208)

    Study variablesn (%)
    Age group
    18 – 25 years52 (25)
    26 – 35 years76 (36.5)
    36 – 45 years59 (28.4)
    >45 years21 (10.1)
    Gender
    Male18 (8.7)
    Female190 (91.3)
    Nationality
    Saudi180 (86.5)
    Non-Saudi28 (13.5)
    Marital status
    Single102 (49.0)
    Married88 (42.3)
    Divorced18 (08.7)
    Educational level
    Uneducated06 (02.9)
    Primary06 (02.9)
    Intermediate06 (02.9)
    Secondary37 (17.8)
    University142 (68.3)
    Higher education11 (05.3)
    Occupation
    Student33 (15.9)
    Unemployed118 (6.7)
    Employed40 (19.2)
    Self-employed9 (4.3)
    Retired8 (03.8)
    Associated comorbidities
    Yes98 (47.1)
    No110 (52.9)
    • SLE - Systemic Lupus Erythematosus

    • View popup
    Table 2

    - Duration of SLE and other related characteristics of patients (n=208).

    Variablesn (%)
    Duration since diagnosed with SLE
    <1 year22 (10.6)
    1–3 years54 (26.0)
    4–6 years47 (22.6)
    7–10 years32 (15.4)
    11–15 years26 (12.5)
    >15 years27 (13.0)
    Family history of SLE
    Yes27 (13.5)
    No180 (86.5)
    Frequent headaches
    Yes99 (8.1)
    No108 (51.9)
    Time since the start of headaches (n=100)
    Before the onset of SLE symptoms28 (29.0)
    Before the onset of SLE symptoms but increased severity afterward17 (17.0)
    After the onset of SLE54 (54.0)
    Knowledge about SLE symptoms
    No89 (42.8)
    Yes, a few of them100 (8.1)
    Yes, a lot of them16 (7.7)
    Yes, all of them03 (01.4)
    Sources of information regarding SLE symptoms*
    E-books and research60 (50.4)
    Social media58 (48.7)
    Treating doctor43 (36.1)
    Friends and relatives20 (16.8)
    Awareness campaigns18 (16.0)
    Others7 (05.9)
    • ↵* Variable with multiple response answers, SLE - Systemic Lupus Erythematosus

    • View popup
    Table 3

    - Relationship between the level of NPSLE among the socio-demographic and other related characteristics of the patients. (n=208)

    FactorNPSLEOR (95% CI)P-valueAOR* (95% CI)P-value
    Yes (n=84)No (n=124)
    n (%)
    Age group
    ≤35 years52 (61.9)76 (61.3)Ref Ref 
    >35 years32 (38.1)48 (38.7)0.9 (0.6 – 1.7)0.9290.9 (0.4 – 1.8)0.736
    Marital status
    Never been married42 (50.0)60 (48.4)Ref Ref 
    Been married42 (50.0)64 (51.6)0.9 (0.5 – 1.6)0.8191.2 (0.6 – 2.5)0.623
    Educational level
    Secondary or below20 (23.8)35 (28.2)Ref Ref 
    University or higher64 (76.2)89 (71.8)1.3 (0.7 – 2.4)0.4791.3 (0.6 – 2.6)0.468
    Occupation
    Student16 (19.0)17 (13.7)Ref Ref 
    Unemployed46 (54.8)80 (64.5)0.9 (0.4 – 2.1)0.7490.6 (0.2 – 1.7)0.372
    Employed22 (26.2)27 (21.8)1.4 (0.7 – 2.8)0.3081.3 (0.6 – 2.8)0.434
    Associated comorbidity
    Yes47 (56.0)51 (41.1)1.8 (1.0 – 3.2)0.036**2.1 (1.2 – 3.8)0.015**
    No37 (44.0)73 (58.9)Ref Ref 
    Duration since diagnosed with SLE
    ≤6 years51 (60.7)72 (58.1)Ref Ref 
    >6 years33 (39.3)52 (41.9)0.9 (0.5 – 1.6)0.7030.9 (0.5 – 1.7)0.739
    Family history of SLE
    Yes17 (20.2)11 (08.9)2.6 (1.2 – 5.9)0.021**3.2 (1.4 – 7.6)0.008**
    No67 (79.8)113 (91.1)Ref Ref 
    Knowledge about SLE symptoms
    Yes52 (61.9)67 (54.0)1.4 (0.8 – 2.4)0.2611.3 (0.7 – 2.4)0.363
    No32 (38.1)57 (46.0)Ref Ref 
    • NPSLE – Neuropsychiatric Systemic Lupus Erythematosus, SLE - Systemic Lupus Erythematosus, OR – Odds Ratio (Crude OR),

    • ↵* AOR – Adjusted Odds Ratio” age, marital status, educational level, occupation, duration since diagnosis with SLE, and knowledge about SLE symptoms”, CI – Confidence Interval

    • ↵** Significant at p<0.05 level

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Neurosciences Journal: 28 (3)
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An evaluation of neuropsychiatric manifestations in systemic lupus erythematosus patients in Saudi Arabia and their associated factors
Yousef M. Alammari, Mahmoud A. Gaddoury, Abdullah A. Alaryni, Abdullah H. Alghamdi, Sara A. Alharbi, Reem A. Almohaini, Lena S. Alsaleem, Lujain H. Allowaihiq, Maha H. Alrashid
Neurosciences Journal Jul 2023, 28 (3) 177-183; DOI: 10.17712/nsj.2023.3.20220127

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An evaluation of neuropsychiatric manifestations in systemic lupus erythematosus patients in Saudi Arabia and their associated factors
Yousef M. Alammari, Mahmoud A. Gaddoury, Abdullah A. Alaryni, Abdullah H. Alghamdi, Sara A. Alharbi, Reem A. Almohaini, Lena S. Alsaleem, Lujain H. Allowaihiq, Maha H. Alrashid
Neurosciences Journal Jul 2023, 28 (3) 177-183; DOI: 10.17712/nsj.2023.3.20220127
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