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Research ArticleOriginal Article
Open Access

Effects of decompressive craniectomy combined with edaravone on postoperative neurological functions and hemodynamics of patients with severe traumatic brain injury

Xinjing Yang
Neurosciences Journal January 2024, 29 (1) 25-31; DOI: https://doi.org/10.17712/nsj.2024.1.20230057
Xinjing Yang
From the Department of Neurosurgery, Medical College, Nanchang University, Nanchang, China
BSc
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  • ORCID record for Xinjing Yang
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    Table 1

    - NCSE score and Barthel index score [(x̅±s), point].

    GroupsnNCSE scoreBarthel index score
    Before treatmentAfter treatmentBefore treatmentAfter treatment
    Operation8245.68±4.5964.23±6.4543.29±4.3172.59±7.28
    Combined medication10445.72±4.5378.45±7.8943.25±4.3681.46±8.17
    t 0.05913.2100.0627.709
    P 0.9530.0010.9500.001
    • View popup
    Table 2

    - Hemodynamics indicators (x̅±s).

    GroupsnHR (beat/min)MAP (mmHg)Ipsilateral blood flow velocity (cm/s)Contralateral blood flow velocity (cm/s)
    Before treatmentAfter treatmentBefore treatmentAfter treatmentBefore treatmentAfter treatmentBefore treatmentAfter treatment
    Operation82102.39±10.2564.29±6.4594.25±9.4363.12±6.3452.39±5.2681.06±8.1152.36±5.2869.54±6.97
    Combined medication104102.44±10.1973.45±7.3894.29±9.3875.46±7.5852.43±5.2195.48±9.5752.33±5.3478.69±7.93
    t 0.0338.8790.02911.8300.05210.9000.0388.236
    P 0.9740.0010.9770.0010.9590.0010.9700.001
    • View popup
    Table 3

    - Myocardial zymogram indicators [(x̅±s), U/L].

    GroupnCKASTCK-MB
    Before treatmentAfter treatmentBefore treatmentAfter treatmentBefore treatmentAfter treatment
    Operation82825.46±82.57348.15±34.8347.58±4.7626.85±2.6936.59±3.6727.48±2.75
    Combined medication104825.49±82.53296.48±29.6747.53±4.8319.64±1.9836.54±3.7121.65±2.18
    t 0.00210.9200.07121.0500.09216.130
    P 0.9980.0010.9440.0010.9270.001
    • View popup
    Table 4

    - Postoperative neurological functions [(x̅±s), pg/mL].

    GroupnESNPYET-1
    Before treatmentAfter treatmentBefore treatmentAfter treatmentBefore treatmentAfter treatment
    Operation8250.68±5.0942.38±4.27325.49±32.57219.67±22.0883.46±8.3765.49±6.58
    Combined medication10450.65±5.1234.19±3.44325.44±32.62178.25±17.8683.44±8.4257.23±5.74
    t 0.04014.4900.01014.1400.0169.133
    P 0.9680.0010.9920.0010.9870.001
    • View popup
    Table 5

    - Treatment outcomes [n (%)].

    GroupsnMarked responseModerate responseNo responseTotal response rate
    Operation8239321171 (86.59)
    Combined medication10466353101 (97.12)
    χ2    7.304
    P    0.007
    • View popup
    Table 6

    - Postoperative 1-year prognosis [n (%)].

    GroupsnGood recoveryModerate disabilitySevere disabilityVegetative survivalDeath
    Operation8226241967
    Combined medication1046428912
    χ2 16.3380.1257.5565.1134.355
    P 0.0010.7230.0060.0240.037
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Effects of decompressive craniectomy combined with edaravone on postoperative neurological functions and hemodynamics of patients with severe traumatic brain injury
Xinjing Yang
Neurosciences Journal Jan 2024, 29 (1) 25-31; DOI: 10.17712/nsj.2024.1.20230057

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Effects of decompressive craniectomy combined with edaravone on postoperative neurological functions and hemodynamics of patients with severe traumatic brain injury
Xinjing Yang
Neurosciences Journal Jan 2024, 29 (1) 25-31; DOI: 10.17712/nsj.2024.1.20230057
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