Skip to main content

Main menu

  • Home
  • Content
    • Latest
    • Ahead of print
    • Archive
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Alerts
    • Feedback
    • Folders
    • Help
  • Other Publications
    • Saudi Medical Journal

User menu

  • My alerts
  • Log in

Search

  • Advanced search
Neurosciences Journal
  • Other Publications
    • Saudi Medical Journal
  • My alerts
  • Log in
Neurosciences Journal

Advanced Search

  • Home
  • Content
    • Latest
    • Ahead of print
    • Archive
  • Info for
    • Authors
    • Reviewers
    • Subscribers
    • Institutions
    • Advertisers
  • About Us
    • About Us
    • Editorial Office
    • Editorial Board
  • More
    • Alerts
    • Feedback
    • Folders
    • Help
  • Follow psmmc on Twitter
  • Visit psmmc on Facebook
  • RSS
Systematic ReviewSystematic Review
Open Access

Risk factors for unexplained early neurological deterioration after intravenous thrombolysis: a meta-analysis

J. Li, C.L. Zhu, C.Y. Zhang, L.M. Li, R. Liu, S. Zhang and M.L. He
Neurosciences Journal April 2025, 30 (2) 92-100; DOI: https://doi.org/10.17712/nsj.2025.2.20230105
J. Li
From The Neurology Department, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China
MM, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.L. Zhu
From The Neurology Department, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China
BM, MM
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
C.Y. Zhang
From The Neurology Department, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China
MM, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
L.M. Li
From The Neurology Department, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China
BM, MM
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
R. Liu
From The Neurology Department, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China
BM, MM
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
S. Zhang
From The Neurology Department, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China
BM, MM
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
M.L. He
From The Neurology Department, Lianyungang Clinical College of Nanjing Medical University, Lianyungang, China
MM, MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.L. He
  • For correspondence: [email protected]
  • Article
  • Figures & Data
  • eLetters
  • Info & Metrics
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Grotta JC.
    Intravenous Thrombolysis for Acute Ischemic Stroke. Continuum (Minneap Minn) 2023; 29: 425-442.
    OpenUrlPubMed
  2. 2.
    1. Marnat G,
    2. Lapergue B,
    3. Gory B,
    4. Kyheng M,
    5. Labreuche J,
    6. Turc G, et al.
    Intravenous thrombolysis with tenecteplase versus alteplase combined with endovascular treatment of anterior circulation tandem occlusions: A pooled analysis of ETIS and TETRIS. Eur Stroke J 2024; 9: 124-134.
    OpenUrlPubMed
  3. 3.↵
    1. Fatovich DM,
    2. Milne WK.
    Thrombolysis with alteplase 3-4.5 hours after acute ischaemic stroke: trial reanalysis adjusted for baseline imbalances. BMJ Evid Based Med 2021; 26: e2.
    OpenUrlFREE Full Text
  4. 4.↵
    1. Sharma A,
    2. Pandit AK,
    3. Mishra B,
    4. Srivastava MVP,
    5. Srivastava AK,
    6. Vishnu VY, et al.
    Early neurological deterioration in acute ischemic stroke. Ir J Med Sci 2024; 193: 949-955.
    OpenUrlPubMed
  5. 5.↵
    1. Shah K,
    2. Clark A,
    3. Desai SM,
    4. Jadhav AP. Causes
    . Predictors, and Timing of Early Neurological Deterioration and Symptomatic Intracranial Hemorrhage After Administration of IV tPA. Neurocrit Care 2022; 36: 123-129.
    OpenUrlPubMed
  6. 6.↵
    1. Hou X,
    2. Chen W,
    3. Xu H,
    4. Zhu Z,
    5. Xu Y,
    6. Chen H.
    The rate of early neurological deterioration occurring after thrombolytic therapy: A meta-analysis. Brain Behav 2019; 9: e01210.
    OpenUrlPubMed
  7. 7.↵
    1. Luo B,
    2. Yuan M,
    3. Kuang W,
    4. Wang Y,
    5. Chen L,
    6. Zhang Y, et al.
    A novel nomogram predicting early neurological deterioration after intravenous thrombolysis for acute ischemic stroke. Heliyon 2024; 10: e23341.
    OpenUrl
  8. 8.↵
    1. Zhu W,
    2. Zhou J,
    3. Ma B,
    4. Fan C.
    Predictors of early neurological deterioration in patients with intracerebral hemorrhage: a systematic review and meta-analysis. J Neurol 2024; 271: 2980-2991.
    OpenUrlPubMed
  9. 9.↵
    1. Cui Y,
    2. Meng WH,
    3. Chen HS.
    Early neurological deterioration after intravenous thrombolysis of anterior vs posterior circulation stroke: a secondary analysis of INTRECIS. Sci Rep 2022; 12: 3163.
    OpenUrlPubMed
  10. 10.↵
    1. Yu WM,
    2. Abdul-Rahim AH,
    3. Cameron AC,
    4. Kõrv J,
    5. Sevcik P,
    6. Toni D, et al.
    The Incidence and Associated Factors of Early Neurological Deterioration After Thrombolysis: Results From SITS Registry. Stroke 2020; 51: 2705-2714.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Jauch EC,
    2. Saver JL,
    3. Adams HP,
    4. Bruno A,
    5. Connors JJ,
    6. Demaerschalk BM, et al.
    Guidelines for the early management of patients with acute ischemic stroke: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2013; 44: 870-947.
    OpenUrlAbstract/FREE Full Text
  12. 12.↵
    1. Heitkamp C,
    2. Winkelmeier L,
    3. Heit JJ,
    4. Albers GW,
    5. Lansberg MG,
    6. Kniep H, et al.
    Early neurological deterioration in patients with acute ischemic stroke is linked to unfavorable cerebral venous outflow. Eur Stroke J 2024; 9: 162-171.
    OpenUrlPubMed
  13. 13.↵
    1. McGrath S,
    2. Zhao X,
    3. Steele R,
    4. Thombs BD,
    5. Benedetti A.
    Estimating the sample mean and standard deviation from commonly reported quantiles in meta-analysis. Stat Methods Med Res 2020; 29: 2520-2537.
    OpenUrlCrossRefPubMed
  14. 14.
    1. Boulenoir N,
    2. Turc G,
    3. Henon H,
    4. Laksiri N,
    5. Mounier-Véhier F,
    6. Girard Buttaz I, et al.
    Early neurological deterioration following thrombolysis for minor stroke with isolated internal carotid artery occlusion. Eur J Neurol 2021; 28: 479-490.
    OpenUrlCrossRefPubMed
  15. 15.
    1. Che F,
    2. Wang A,
    3. Ju Y,
    4. Ding Y,
    5. Duan H,
    6. Geng X, et al.
    Early neurological deterioration in acute ischemic stroke patients after intravenous thrombolysis with alteplase predicts poor 3-month functional prognosis - data from the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China). BMC Neurol 2022; 22: 212.
    OpenUrlPubMed
  16. 16.
    1. Huang S,
    2. Shen H,
    3. Xing P,
    4. Shen F,
    5. Zhang Y,
    6. Wu T, et al.
    Related factors and clinical feature analysis of unexplained early neurological deterioration after intravenous thrombolysis. Acad J Second Mil Med Univers 2018; 39: 1023-1027.
    OpenUrl
  17. 17.
    1. Tanaka K,
    2. Matsumoto S,
    3. Furuta K,
    4. Yamada T,
    5. Nagano S,
    6. Takase KI, et al.
    Differences between predictive factors for early neurological deterioration due to hemorrhagic and ischemic insults following intravenous recombinant tissue plasminogen activator. J Thromb Thrombolysis 2020; 49: 545-550.
    OpenUrlCrossRefPubMed
  18. 18.
    1. Li L,
    2. Ma Q.
    Influencing factors of early neurological deterioration after intravenous thrombolysis in acute cerebral infarction. Chin J Cerebrovas Dis 2019; 19 16: 628-632.
    OpenUrl
  19. 19.
    1. Li N,
    2. Wu F,
    3. Li T,
    4. Hou Q,
    5. Ji W,
    6. Cai D, et al.
    Risk factors for early neurological deterioration in elderly patients with acute ischemic stroke after intravenous thrombolysis. Chin J Geriat 2021; 40: 1005-1009.
    OpenUrl
  20. 20.
    1. Liu G,
    2. Dai J,
    3. Ma Y,
    4. Chen Y,
    5. Liao X,
    6. Zou A, et al.
    Retracted: Influencing Factors of Early Neurological Deterioration and Short-Term Prognosis after Intravenous Thrombolysis in Patients with Acute Ischemic Stroke. Evid Based Complement Alternat Med 2023; 2023: 9827912.
    OpenUrlPubMed
  21. 21.
    1. Mori M,
    2. Naganuma M,
    3. Okada Y,
    4. Hasegawa Y,
    5. Shiokawa Y,
    6. Nakagawara J, et al.
    Early neurological deterioration within 24 hours after intravenous rt-PA therapy for stroke patients: the Stroke Acute Management with Urgent Risk Factor Assessment and Improvement rt-PA Registry. Cerebrovasc Dis 2012; 34: 140-146.
    OpenUrlCrossRefPubMed
  22. 22.
    1. Seners P,
    2. Ben Hassen W,
    3. Lapergue B,
    4. Arquizan C,
    5. Heldner MR,
    6. Henon H, et al.
    Prediction of Early Neurological Deterioration in Individuals With Minor Stroke and Large Vessel Occlusion Intended for Intravenous Thrombolysis Alone. JAMA Neurol 2021; 78: 321-328.
    OpenUrlPubMed
  23. 23.
    1. Seners P,
    2. Turc G,
    3. Tisserand M,
    4. Legrand L,
    5. Labeyrie MA,
    6. Calvet D, et al.
    Unexplained early neurological deterioration after intravenous thrombolysis: incidence, predictors, and associated factors. Stroke 2014; 45: 2004-2009.
    OpenUrlAbstract/FREE Full Text
  24. 24.
    1. Seners P,
    2. Hurford R,
    3. Tisserand M,
    4. Turc G,
    5. Legrand L,
    6. Naggara O, et al.
    Is Unexplained Early Neurological Deterioration After Intravenous Thrombolysis Associated With Thrombus Extension? Stroke 2017; 48: 348-352.
    OpenUrlAbstract/FREE Full Text
  25. 25.
    1. Simonsen CZ,
    2. Schmitz ML,
    3. Madsen MH,
    4. Mikkelsen IK,
    5. Chandra RV,
    6. Leslie-Mazwi T, et al.
    Early neurological deterioration after thrombolysis: Clinical and imaging predictors. Int J Stroke 2016; 11: 776-782.
    OpenUrlCrossRefPubMed
  26. 26.
    1. Wang L,
    2. Cheng Q,
    3. Hu T,
    4. Wang N,
    5. Wei X,
    6. Wu T, et al.
    Impact of Stress Hyperglycemia on Early Neurological Deterioration in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis. Front Neurol 2022; 13: 870872.
    OpenUrlPubMed
  27. 27.↵
    1. Parray A,
    2. Ma Y,
    3. Alam M,
    4. Akhtar N,
    5. Salam A,
    6. Mir F, et al.
    An increase in AMPK/e-NOS signaling and attenuation of MMP-9 may contribute to remote ischemic perconditioning associated neuroprotection in rat model of focal ischemia. Brain Res 2020; 1740: 146860.
    OpenUrlPubMed
  28. 28.↵
    1. Yamazaki Y,
    2. Abe Y,
    3. Fujii S,
    4. Tanaka KF.
    Oligodendrocytic Na(+)-K(+)-Cl(-) co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain. Nat Commun 2021; 12: 5146.
    OpenUrlCrossRefPubMed
  29. 29.↵
    1. Choi JW,
    2. Ryoo IW,
    3. Hong JY,
    4. Lee KY,
    5. Nam HS,
    6. Kim WC, et al.
    Clinical impact of estradiol/testosterone ratio in patients with acute ischemic stroke. BMC Neurol 2021; 21: 91.
    OpenUrlPubMed
  30. 30.↵
    1. Abi-Ghanem C,
    2. Robison LS,
    3. Zuloaga KL.
    Androgens’ effects on cerebrovascular function in health and disease. Biol Sex Differ 2020; 11: 35.
    OpenUrlPubMed
  31. 31.↵
    1. Sohrabji F,
    2. Okoreeh A,
    3. Panta A.
    Sex hormones and stroke: Beyond estrogens. Horm Behav 2019; 111: 87-95.
    OpenUrlCrossRefPubMed
  32. 32.↵
    1. Wang J,
    2. Zhong Y,
    3. Zhu H,
    4. Mahgoub OK,
    5. Jian Z,
    6. Gu L,et al.
    Different gender-derived gut microbiota influence stroke outcomes by mitigating inflammation. J Neuroinflammation 2022; 19: 245.
    OpenUrlCrossRefPubMed
  33. 33.↵
    1. He J,
    2. Fu F,
    3. Zhang W,
    4. Zhan Z,
    5. Cheng Z.
    Prognostic significance of the clinical and radiological haemorrhagic transformation subtypes in acute ischaemic stroke: A systematic review and meta-analysis. Eur J Neurol 2022; 29: 3449-3459.
    OpenUrlPubMed
  34. 34.↵
    1. Yi X,
    2. Wang C,
    3. Liu P,
    4. Fu C,
    5. Lin J,
    6. Chen Y.
    Antiplatelet drug resistance is associated with early neurological deterioration in acute minor ischemic stroke in the Chinese population. J Neurol 2016; 263: 1612-1619.
    OpenUrlPubMed
  35. 35.↵
    1. Sabir Rashid A,
    2. Huang-Link Y,
    3. Johnsson M,
    4. Wetterhäll S,
    5. Gauffin H.
    Predictors of Early Neurological Deterioration and Functional Outcome in Acute Ischemic Stroke: The Importance of Large Artery Disease, Hyperglycemia and Inflammatory Blood Biomarkers. Neuropsychiatr Dis Treat 2022; 18: 1993-2002.
    OpenUrlCrossRefPubMed
  36. 36.↵
    1. Zhao M,
    2. Zhong X,
    3. Du J,
    4. He L,
    5. Wang J.
    Predictive factors for early neurological deterioration after intravenous thrombolysis of single subcortical infarction in the territory of the middle cerebral artery. Brain Behav 2023; 13: e3283.
    OpenUrlPubMed
  37. 37.↵
    1. Jiang M,
    2. Wu H,
    3. Zhang H,
    4. Su F,
    5. Cao L,
    6. Ren X, et al.
    Association between the Triglyceride-Glucose Index and the Risk of Large Artery Atherosclerotic Stroke. Int J Clin Pract 2022; 2022: 5191581.
    OpenUrlPubMed
  38. 38.
    1. Nam KW,
    2. Kwon HM,
    3. Lee YS.
    Triglyceride-Related Parameters and Symptomatic Atherosclerotic Lesions in Patients With Ischemic Stroke. J Lipid Atheroscler 2024; 13: 155-165.
    OpenUrlPubMed
  39. 39.↵
    1. Wang Y,
    2. Liu T,
    3. Li Y,
    4. Zhang K,
    5. Fan H,
    6. Ren J, et al.
    Triglyceride-glucose index, symptomatic intracranial artery stenosis and recurrence risk in minor stroke patients with hypertension. Cardiovasc Diabetol 2023; 22: 90.
    OpenUrlPubMed
  40. 40.↵
    1. Kelly PJ,
    2. Lemmens R,
    3. Tsivgoulis G.
    Inflammation and Stroke Risk: A New Target for Prevention. Stroke 2021; 52: 2697-2706.
    OpenUrlCrossRefPubMed
  41. 41.↵
    1. Wang H,
    2. Hong LJ,
    3. Huang JY,
    4. Jiang Q,
    5. Tao RR,
    6. Tan C, et al.
    P2RX7 sensitizes Mac-1/ICAM-1-dependent leukocyte-endothelial adhesion and promotes neurovascular injury during septic encephalopathy. Cell Res 2015; 25: 674-690.
    OpenUrlCrossRefPubMed
  42. 42.↵
    1. Wu F,
    2. Han Y,
    3. Xiong Q,
    4. Tang H,
    5. Shi J,
    6. Yang Q, et al.
    Cerebral Endothelial CXCR2 Promotes Neutrophil Transmigration into Central Nervous System in LPS-Induced Septic Encephalopathy. Biomedicines 2024; 12.
  43. 43.↵
    1. Vollrath JT,
    2. Stoermann P,
    3. Becker N,
    4. Wutzler S,
    5. Hildebrand F,
    6. Marzi I,
    7. Relja B.
    Early local neutralization of CC16 in sepsis-induced ALI following blunt chest trauma leads to delayed mortality without benefitting overall survival. Int J Mol Med 2020; 46: 2207-2215.
    OpenUrlPubMed
PreviousNext
Back to top

In this issue

Neurosciences Journal: 30 (2)
Neurosciences Journal
Vol. 30, Issue 2
1 Apr 2025
  • Table of Contents
  • Cover (PDF)
  • Index by author
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on Neurosciences Journal.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Risk factors for unexplained early neurological deterioration after intravenous thrombolysis: a meta-analysis
(Your Name) has sent you a message from Neurosciences Journal
(Your Name) thought you would like to see the Neurosciences Journal web site.
Citation Tools
Risk factors for unexplained early neurological deterioration after intravenous thrombolysis: a meta-analysis
J. Li, C.L. Zhu, C.Y. Zhang, L.M. Li, R. Liu, S. Zhang, M.L. He
Neurosciences Journal Apr 2025, 30 (2) 92-100; DOI: 10.17712/nsj.2025.2.20230105

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Risk factors for unexplained early neurological deterioration after intravenous thrombolysis: a meta-analysis
J. Li, C.L. Zhu, C.Y. Zhang, L.M. Li, R. Liu, S. Zhang, M.L. He
Neurosciences Journal Apr 2025, 30 (2) 92-100; DOI: 10.17712/nsj.2025.2.20230105
Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Bookmark this article

Jump to section

  • Article
    • ABSTRACT
    • Methods
    • Results
    • Discussion
    • Acknowledgments
    • Footnotes
    • References
  • Figures & Data
  • eLetters
  • References
  • Info & Metrics
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Diagnostic effectiveness of deep learning-based MRI in predicting multiple sclerosis: A meta-analysis
  • Management of Lennox-Gastaut syndrome with deep brain stimulation: A systematic literature review
Show more Systematic Review

Similar Articles

Navigate

  • home

More Information

  • Help

Additional journals

  • All Topics

Other Services

  • About

© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

Powered by HighWire