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Research ArticleOriginal Article
Open Access

Early versus late surgical decompression for traumatic thoracic/thoracolumbar (T1-L1) spinal cord injured patients

Primary results of a randomized controlled trial at one year follow-up

Vafa Rahimi-Movaghar, Amin Niakan, Ali Haghnegahdar, Abtin Shahlaee, Soheil Saadat and Ehsan Barzideh
Neurosciences Journal July 2014, 19 (3) 183-191;
Vafa Rahimi-Movaghar
From the Sina Trauma and Surgery Research Center (Rahimi-Movaghar, Shahlaee, Saadat), Sina Hospital, the Students’ Scientific Research Center (Shahlaee), Tehran University of Medical Sciences, Tehran, the Department of Neurosurgery (Niakan, Haghnegahdar, Barzideh), and the Trauma Research Center (Niakan, Haghnegahdar, Barzideh), Shahid Rajaee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
MD
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  • For correspondence: [email protected] [email protected]
Amin Niakan
From the Sina Trauma and Surgery Research Center (Rahimi-Movaghar, Shahlaee, Saadat), Sina Hospital, the Students’ Scientific Research Center (Shahlaee), Tehran University of Medical Sciences, Tehran, the Department of Neurosurgery (Niakan, Haghnegahdar, Barzideh), and the Trauma Research Center (Niakan, Haghnegahdar, Barzideh), Shahid Rajaee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
MD
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Ali Haghnegahdar
From the Sina Trauma and Surgery Research Center (Rahimi-Movaghar, Shahlaee, Saadat), Sina Hospital, the Students’ Scientific Research Center (Shahlaee), Tehran University of Medical Sciences, Tehran, the Department of Neurosurgery (Niakan, Haghnegahdar, Barzideh), and the Trauma Research Center (Niakan, Haghnegahdar, Barzideh), Shahid Rajaee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
MD
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Abtin Shahlaee
From the Sina Trauma and Surgery Research Center (Rahimi-Movaghar, Shahlaee, Saadat), Sina Hospital, the Students’ Scientific Research Center (Shahlaee), Tehran University of Medical Sciences, Tehran, the Department of Neurosurgery (Niakan, Haghnegahdar, Barzideh), and the Trauma Research Center (Niakan, Haghnegahdar, Barzideh), Shahid Rajaee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
MD
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Soheil Saadat
From the Sina Trauma and Surgery Research Center (Rahimi-Movaghar, Shahlaee, Saadat), Sina Hospital, the Students’ Scientific Research Center (Shahlaee), Tehran University of Medical Sciences, Tehran, the Department of Neurosurgery (Niakan, Haghnegahdar, Barzideh), and the Trauma Research Center (Niakan, Haghnegahdar, Barzideh), Shahid Rajaee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
MD, PhD
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Ehsan Barzideh
From the Sina Trauma and Surgery Research Center (Rahimi-Movaghar, Shahlaee, Saadat), Sina Hospital, the Students’ Scientific Research Center (Shahlaee), Tehran University of Medical Sciences, Tehran, the Department of Neurosurgery (Niakan, Haghnegahdar, Barzideh), and the Trauma Research Center (Niakan, Haghnegahdar, Barzideh), Shahid Rajaee Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
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Article Figures & Data

Figures

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  • Figure 1
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    Figure 1

    Flow diagram of traumatic spinal cord injury patient selection, randomization, and follow-up.

  • Figure 2
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    Figure 2

    American Spinal Injury Association Impairment Scale (AIS) Grade Improvement at 12 months: A) early versus B) late surgery in traumatic spinal cord injury patients.

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    Figure 3

    Mean American Spinal Injury Association (ASIA) motor score at baseline and over 1-month, 3-month, 6-month, and 12-month postoperative (post-op) follow-up visits in incomplete traumatic spinal cord injury (SCI) and early versus late surgery groups. No change in motor score was observed in patients with complete traumatic spinal cord injury.

Tables

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    Table 1

    Patient baseline and group characteristics among traumatic spinal cord injury patients.

    CharacteristicsOverall (n=35)Early surgery (n=16)Late surgery (n=19)P-value
    Age, mean±SD35±12.0731.7±9.137.8±13.700.126
    Gender, n (%)0.748
     Male25 (71)11 (69)14 (74)
     Female10 (29)5 (31)5 (26)
    Etiology, n (%)0.027
     Automobile crashes18 (51)4 (25)14 (74)
     Motorcycle crashes5 (14)3 (19)2 (10)
     Fall10 (29)7 (44)3 (16)
     Other2 (6)2 (12)0
    Baseline AIS grade, n (%)0.254
     A16 (46)7 (44)9 (47)
     B6 (17)1 (6)5 (26)
     C5 (14)4 (25)1 (5)
     D8 (23)4 (25)4 (21)
     Hospitalization days, mean±SD8.5±7.787±7.139.7±8.280.328
     Time to surgery, mean hours±SD32.7±16.018.9±4.7545±11.93<0.001
    Distribution of vertebral fractures, n (%)0.728
     L111 (31)7 (44)4 (21)
     T1212 (34)5 (31)7 (37)
     T113 (9)1 (6)2 (11)
     T102 (6)02 (11)
     T92 (6)1 (6)1 (5)
     T83 (9)1 (6)2 (11)
     T7000
     T61 (3)01 (5)
     T51 (3)1 (6)0
    Magerl classification of vertebral fracture, n (%)0.752
     A37 (20)2 (13)5 (26)
     B11 (3)01 (5)
     B26 (17)3 (19)3 (16)
     B31 (3)1 (6)0
     C18 (23)5 (31)3 (16)
     C26 (17)2 (13)4 (21)
     C36 (17)3 (19)3 (16)
    Surgical technique, n (%)0.987
     Short-segment including*18 (51)9 (56)9 (47)
     Short-segment non-including1 (3)01 (5)
     Long-segment including5 (14)2 (13)3 (16)
     Long-segment non-including7 (20)3 (19)4 (21)
     360º†4 (11)2 (13)2 (11)
    • ↵* Including means the insertion of pedicle screws in the broken/fractured vertebra as a fixation point.

    • ↵† 360º procedure means a 2-staged operation with posterior and anterior approaches

    • View popup
    Table 2

    Characteristics of traumatic spinal cord injury patients enrolled in the study.

    Case #AgeGenderLevelEtiologyE/LC/IMagerlBaseline AISF/U AISF/USurgical techniqueHRLHRARLAR
    120FT12CCEIC1DE12SI700140
    232ML1CCLIA3DE12SI300200
    348MT12CCLCC2AB12SI8000
    436ML1CCLIC1BC12SNI383144
    520ML1CCECC2AA12SI50240
    645ML1MCEIA3DE12SI15002
    726ML1FDEIB2CD12SI441242
    834FT12FDEIC1CC12360°500200
    951ML1MCEIC1CE12SI2210586
    1028FT10CCLCC3AA12LI00120
    1142FL1CCLIB2C-DLI150120
    1229MT12FDECC1AA12LI17070
    1329FT12CCECC3AB12SI0000
    1454FT12CCLIA3DD12SI400100
    1529MT11FDECC3A-DLNI150160
    1628ML1CCLIC1DD12360°32040
    1723ML1MCEIC1CE12LI15000
    1836MT8EtcECC3AA12LNI20240
    1957MT11CCLCC2AA12SI45580
    2045MT8CCLCB2AA12SI015416
    2145FT9FDECC2AA12360°30000
    2221MT6MCLCC2AA12SI50230
    2325MT12FDLCA3AA12360°50060
    2435MT12CCEIA3BD12SI40060
    2568MT11FDLIB2BD12LNI5064
    2623MT8MCLCC3AA12LI5030014
    2740MT12CCLIC2BC12SI80622
    2827MT9FDLIB1BC12SI201534
    2950FT12CCLCC1AA12LNI51800
    3034ML1FDEIB3DD12SI35060
    3122MT12CCLIA3BC12LNI350160
    3225MT12CCLCC3AA12LNI0000
    3347FT10CCLIA3DE12SI103520
    3425MT5FDECB2AA12LNI3315814
    3526FL1EtcEIB2DE12SI40080
      • View popup
      Table 3

      Description of restoration/rebuilding of vertebral height and reduction of kyphotic angle one week after surgery, and one year loss of restoration/rebuilding between groups among traumatic spinal cord injury (SCI) patients.

      VariableIncomplete SCIP-valueComplete SCIP-value
      Early surgery (n=9)Late surgery (n=10)Early surgery (n=7)Late surgery (n=9)
      Mean height restoration (%)36.8 ± 17.7523.3 ± 13.240.07614.6 ± 13.2023.2 ± 24.650.417
      Mean height loss of restoration (%)1.2 ± 3.315.3 ± 11.440.3182.1 ± 5.676.4 ± 10.250.337
      Mean angle reduction (°)15.1 ± 18.099.3 ± 6.070.35011.2 ± 10.245.8 ± 7.720.248
      Mean angle loss of reduction (°)1.1 ± 2.033.4 ± 6.80.3462 ± 5.293.3 ± 6.630.671
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    Neurosciences Journal: 19 (3)
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    1 Jul 2014
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    Early versus late surgical decompression for traumatic thoracic/thoracolumbar (T1-L1) spinal cord injured patients
    Vafa Rahimi-Movaghar, Amin Niakan, Ali Haghnegahdar, Abtin Shahlaee, Soheil Saadat, Ehsan Barzideh
    Neurosciences Journal Jul 2014, 19 (3) 183-191;

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    Early versus late surgical decompression for traumatic thoracic/thoracolumbar (T1-L1) spinal cord injured patients
    Vafa Rahimi-Movaghar, Amin Niakan, Ali Haghnegahdar, Abtin Shahlaee, Soheil Saadat, Ehsan Barzideh
    Neurosciences Journal Jul 2014, 19 (3) 183-191;
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