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Case ReportCase Report
Open Access

Thrombolytic therapy at systemic lupus onset with secondary antiphospholipid syndrome

A rare stroke experience

Juned J. Loharia, Junaid M. Alam, Hassan A. Abdelhadi and Tamer F. Marei
Neurosciences Journal January 2015, 20 (1) 55-60;
Juned J. Loharia
From the Department of Internal Medicine-ICU (Loharia, Alam), the Department of Internal Medicine-Neurology (Abdelhadi), and the Department of Medical Imaging (Marei), Imam Abdulrahman Binfaisal Hospital, National Guard Health Affairs, Dammam, Kingdom of Saudi Arabia
MD, MRCP(UK)
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Junaid M. Alam
From the Department of Internal Medicine-ICU (Loharia, Alam), the Department of Internal Medicine-Neurology (Abdelhadi), and the Department of Medical Imaging (Marei), Imam Abdulrahman Binfaisal Hospital, National Guard Health Affairs, Dammam, Kingdom of Saudi Arabia
DABIM
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  • For correspondence: [email protected] [email protected]
Hassan A. Abdelhadi
From the Department of Internal Medicine-ICU (Loharia, Alam), the Department of Internal Medicine-Neurology (Abdelhadi), and the Department of Medical Imaging (Marei), Imam Abdulrahman Binfaisal Hospital, National Guard Health Affairs, Dammam, Kingdom of Saudi Arabia
MRCP(UK), FRCP(Ed)
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Tamer F. Marei
From the Department of Internal Medicine-ICU (Loharia, Alam), the Department of Internal Medicine-Neurology (Abdelhadi), and the Department of Medical Imaging (Marei), Imam Abdulrahman Binfaisal Hospital, National Guard Health Affairs, Dammam, Kingdom of Saudi Arabia
MBBCh, FRCR
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    Figure 1

    Non-contrast CT scan brain showing A) and C) no CT signs of acute infarction or hemorrhage. B) Axial image and D) Coronal image showing focal hyper-density at the M2 segment of the left middle cerebral artery (MCA dot sign).

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    Figure 2

    Magnetic resonance imaging with diffusion-weighted image (DWI), apparent diffusion coefficient (ADC) and axial fluid attenuated inversion recovery (FLAIR) WI showing: A) Acute infarction of the left lentiform nucleus and corona radiata region with high signal on DWI (arrow in A); B) Low signal on ADC (arrow in B); C) FLAIR WI with loss of the normal signal void along the M2 and M3 branches of the left middle cerebral artery (arrow in C) implying slow blood flow.

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    Figure 3

    3-D time-of-flight magnetic resonance angiogram (3 hours after stroke onset) showed A) left middle cerebral (MCA) segment with contrast enhancement, B), C), & D) signal attenuation from the M2 segment of the left MCA depicted with arrows graded as partial thrombo-embolic occlusion.

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    Figure 4

    Maximum intensity projection 3-D time-of-flight magnetic resonance angiogram of the circle of Willis (3 hours and 30 minutes after stroke onset) showing: A and B) thrombo-embolic filling defect at the M2 segment (short white arrows in A and B), narrowing distal M2 segment (short grey arrows in A and B) and pruning of M3 segment branches (long white arrow in A and B) of the left middle cerebral artery.

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    Figure 5

    Non-contrast CT scan brain (26 hours after stroke [22 hours after IV thrombolysis]) showed: A) previously seen hyperdense left middle cerebral artery dot sign in the M2 segment is less prominent. B), C) and D) showed acute linear infarction at the left lentiform and head of caudate nuclei.

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    Figure 6

    Follow up coronal A) and axial B) maximum intensity projection 3-D time-of-flight magnetic resonance angiogram, axial fluid attenuated inversion recovery [FLAIR] C) and coronal D) T2 WI MRI showing: A) Patent M2 segment of left middle cerebral artery. B) Good filling of M3 segment branches. C) Chronic infarction at left lentiform nucleus. D) Chronic infarction at head of caudate nucleus.

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    Table 1

    Complete laboratory test data (some test results were rechecked on follow-up as shown by values with / sign).

    Laboratory testReferencePatient value
    Hemoglobin (g/dl)12 - 1612
    White blood count (Ku/L)4 - 113.2
    Platelets (Ku/L)150 - 400180
    MCV (fl)76 - 9681.6
    MCH (pg)27 - 3225.3
    ESR (mm/hr)0 - 2044
    BUN (mmol/L)2.5 - 6.74.3
    Creatinine (umol/L)50 - 9859
    Blood sugar (mmol/L)2.9 - 7.85.6
    LDL (mmol/L)< 2.62.25
    PT (second/s)11 - 14.512.4
    PTT (seconds/s)26.1 - 37.336.1
    INR0.8 - 1.21
    TSH0.35 - 4.948.09 / 5.27
    Free T4 (pmol/L)9 - 1910.34 / 11.56
    25-OH Vit D (nmol/L)75 - 25078.4
    CRP (mg/L)< 56.7 / 4.1
    Fibrin degradation product (mg/L)0 - 0.52.9
    Fibrinogen (gm/L)1.5 - 4.11.6
    Anti-CCP IgG antibody (unit)< 200.84
    Sickle cell screeningNegative
    ANA index< 1.2> 12
    AntiDNA (IU/ml)< 2052.8
    Vitamin B12 (pmol/L)132 - 857175
    Homocysteine (umol/L)< 157.9
    Antithrombin III (%)75 - 125106
    Functional protein C (%)70 - 130104
    Protein S activity (%)65 - 14069.8
    APC resistance (%)0.9 - 1.30.9
    Factor 5 assay (unit/ml)0.5 - 1.50.74
    Lupus anticoagulant ratio0 - 1.22.1 / 2.5
     LA 1 (secs)30 - 4385.1 / 131
     LA 2 (secs)26.5 - 32.539.6 / 52.6
    Beta-2 glycoprotein
     IgG (U/ml)< 1035.68
     IgM (U/ml)< 123.59
     IgA (U/ml)< 36.43
    Anticardiolipin antibody
     IgG (GPL Unit/ml)< 1037.76 / 34.06
     IgM (MPL Unit/ml)< 76.02 / 6.30
     IgA (APL Unit/ml)< 106.23 / 8.57
     CANCA (U/ml)< 101.48
     PANCA (U/ml)< 64.78
     C3 (g/L)0.83 - 1.931.05
     C4 (g/L)0.150 - 0.5700.362
     Anti SM (U/ml)< 55.04
     Anti SS-A (U/ml)< 48.26
     Anti SS-B (U/ml)< 41.28
     24 hr urine protein (gm/day) - (g/L)0.05 - 0.14< 0.07
     24 hr urine creatinine (mmol/day)06.3 - 14.68.0
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    Neurosciences Journal: 20 (1)
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    1 Jan 2015
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    Thrombolytic therapy at systemic lupus onset with secondary antiphospholipid syndrome
    Juned J. Loharia, Junaid M. Alam, Hassan A. Abdelhadi, Tamer F. Marei
    Neurosciences Journal Jan 2015, 20 (1) 55-60;

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    Thrombolytic therapy at systemic lupus onset with secondary antiphospholipid syndrome
    Juned J. Loharia, Junaid M. Alam, Hassan A. Abdelhadi, Tamer F. Marei
    Neurosciences Journal Jan 2015, 20 (1) 55-60;
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