Research ArticleOriginal Article
Open Access

Effects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in rats

Ersin Beyazcicek, Seyit Ankarali, Ozge Beyazcicek, Handan Ankarali, Serif Demir and Recep Ozmerdivenli
Neurosciences Journal April 2016, 21 (2) 131-137; DOI: https://doi.org/10.17712/nsj.2016.2.20150781

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  • Figure 1
    Figure 1

    Representative electrocorticography (ECoG) samples are presented in the 5-10 minutes from chemicals, or in the 15-30 minutes from penicillin administration. A) Baseline ECoG activity before penicillin injection. B) Epileptiform activity was not observed during recordings in the thymoquinone (TQ) only administration group. C) Intraperitoneal injection of Dimethylsulfoxide (DMSO) did not change the frequency of penicillin-induced epileptiform activity. D) Intracortical injection of penicillin (500 IU) induced epileptiform activity on ECoG. E, F, & G) Administration of TQ (10, 50, and 100mg/kg i.p.) decreased the frequency of epileptiform activity.

  • Figure 2
    Figure 2

    Latency of the first epileptiform activity. *Significance compared with the control group (p<0.05); ∆significance compared with the dimethylsulfoxide (DMSO) group (p<0.05).

  • Figure 3
    Figure 3

    Median values of spike wave frequency (number/min) obtained from recording after penicillin. *Significance compared with the control group (p<0.05); ∆significance compared with the dimethylsulfoxide (DMSO) group; ∑significance compared with the 50 mg/kg thymoquinone (TQ) group (p<0.05).

  • Figure 4
    Figure 4

    Spike wave amplitude (mV) median values obtained from recording after penicillin. *Significance compared with the control group (p<0.05); ∆significance compared with the dimethylsulfoxide (DMSO) group; +significance compared with the 10mg/kg thymoquinone (TQ) group (p<0.05); ∑significance compared with the 50 mg/kg TQ group (p<0.05).

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