Effects of thymoquinone, the major constituent of Nigella sativa seeds, on penicillin-induced epileptiform activity in rats

References

1. ↵
   1. McDaniel SS,
   2. Wong M

   (2011) Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis. Neurosci Let 497, 231–239.
2. ↵
   1. Ngugi AK,
   2. Kariuki SM,
   3. Bottomley C,
   4. Kleinschmidt I,
   5. Sander JW,
   6. Newton CR

   (2011) Incidence of epilepsy: a systematic review and meta-analysis. Neurology 77, 1005–1012.
3. ↵
   1. Ghosheh OA,
   2. Houdi AA,
   3. Crooks PA

   (1999) High performance liquid chromatographic analysis of the pharmacologically active quinones and related compounds in the oil of the black seed (Nigella sativa L.). J Pharm Biomed Anal 19, 757–762.
4. ↵
   1. El-Dakhakhny M

   (1963) Studies on the chemical constituents of Egyptian Nigella sativa L. seeds. The essential oil. Planta Med 11, 465–470.
5. ↵
   1. Ashraf SS,
   2. Rao MV,
   3. Kaneez FS,
   4. Qadri S,
   5. Al-Marzouqi AH,
   6. Chandranath IS,
   7. et al.

   (2011) Nigella sativa extract as a potent antioxidant for petrochemical-ınduced oxidative stress. J Chromatogr Sci 49, 321–326.
6. ↵
   1. Gholamnezhad Z,
   2. Keyhanmanesh R,
   3. Boskabady MH

   (2015) Anti-inflammatory, antioxidant, and immunomodulatory aspects of Nigella sativa for its preventive and bronchodilatory effects on obstructive respiratory diseases: A review of basic and clinical evidence. Journal of Functional Foods 17, 910–927.
7. ↵
   1. Orient A,
   2. Donkó A,
   3. Szabó A,
   4. Leto TL,
   5. Geiszt M

   (2007) Novel sources of reactive oxygen species in the human body. Nephrol Dial Transplant 22, 1281–1288.
8. ↵
   1. Elmowalid G,
   2. Amar AM,
   3. Ahmad AA

   (2013) Nigella sativa seed extract: 1 Enhancement of sheep macrophage immune functions in vitro. Res Vet Sci 95, 437–443.
9. ↵
   1. Bakathir HA,
   2. Abbas NA

   (2011) Detection of the antibacterial effect of Nigella sativa ground seeds with water. Afr J Tradit Complement Altern Med 8, 159–164.
10. ↵
    1. Koka PS,
    2. Mondal D,
    3. Schultz M,
    4. Abdel-Mageed AB,
    5. Agrawal KC

    (2010) Studies on molecular mechanisms of growth inhibitory effects of thymoquinone against prostate cancer cells: role of reactive oxygen species. Exp Biol Med (Maywood) 235, 751–760.
11. ↵
    1. Qadri S,
    2. Mahmud H,
    3. Föller M,
    4. Lang F

    (2009) Thymoquinone-induced suicidal erythrocyte death. Food Chem Toxicol 47, 1545–1549.
12. ↵
    1. Asgary S,
    2. Sahebkar A,
    3. Goli-malekabad N

    (2015) Ameliorative effects of Nigella sativa on dyslipidemia. J Endocrinol Invest 38, 1039–1046.
13. ↵
    1. Radad K,
    2. Hassanein K,
    3. Al-Shraim M,
    4. Moldzio R,
    5. Rausch WD

    (2014) Thymoquinone ameliorates lead-induced brain damage in Sprague Dawley rats. Exp Toxicol Pathol 66, 13–17.
14. ↵
    1. Ahlatci A,
    2. Kuzhan A,
    3. Taysi S,
    4. Demirtas OC,
    5. Alkis HE,
    6. Tarakcioglu M,
    7. et al.

    (2014) Radiation-modifying abilities of Nigella sativa and Thymoquinone on radiation-induced nitrosative stress in the brain tissue. Phytomedicine 21, 740–744.
15. ↵
    1. Alhebshi AH,
    2. Gotoh M,
    3. Suzuki I

    (2013) Thymoquinone protects cultured rat primary neurons against amyloid b-induced neurotoxicity. Biochem Biophys Res Commun 433, 362–367.
16. ↵
    1. Akhondian J,
    2. Kianifar H,
    3. Raoofziaee M,
    4. Moayedpour A,
    5. Toosi MB,
    6. Khajedaluee M

    (2011) The effect of thymoquinone on intractable pediatric seizures (pilot study). Epilepsy Res 93, 39–43.
17. ↵
    1. Hosseinzadeh H,
    2. Parvardeh S,
    3. Nassiri-Asl M,
    4. Mansouri MT

    (2005) Intracerebroventricular administration of thymoquinone, the major constituent of Nigella sativa seeds, suppresses epileptic seizures in rats. Med Sci Monit 11, BR106–BR110.
18. ↵
    1. Khazdair MR

    (2015) The Protective Effects of Nigella sativa and Its Constituents on Induced Neurotoxicity. J Toxicol, 841823.
19. ↵
    1. Hosseinzadeh H,
    2. Parvardeh S

    (2004) Anticonvulsant effects of thymoquinone, the major constituent of Nigella sativa seeds, in mice. Phytomedicine 11, 56–64.
20. ↵
    1. Raza M,
    2. Alghasham AA,
    3. Alorainy MS,
    4. El-Hadiyah TM

    (2008) Potentiation of Valproate-induced Anticonvulsant response by Nigella sativa seed constituents: The Role of GABA Receptors. Int J Health Sci (Qassim) 2, 15–25.
21. ↵
    1. Bahadir A,
    2. Demir S,
    3. Orallar H,
    4. Beyazcicek E,
    5. Oner F

    (2015) Effects of an Extract of Salvia Miltiorrhiza on a Penicillin-Induced Epilepsy Model in Rats. Neurophysiology 47, 218–224.
22. ↵
    1. Cakil D,
    2. Yildirim M,
    3. Ayyildiz M,
    4. Agar E

    (2011) The effect of co-administration of the NMDA blocker with agonist and antagonist of CB1-receptor on penicillin-induced epileptiform activity in rats. Epilepsy Res 93, 128–137.
23. ↵
    1. Yildirim M,
    2. Marangoz AH,
    3. Ayyildiz M,
    4. Ankarali S,
    5. Marangoz C

    (2011) The interactions of nitric oxide and adenosine on penicillin-induced epileptiform activity in rats. Acta Neurobiol Exp (Wars) 71, 208–219.
24. ↵
    1. Albertson AJ,
    2. Williams SB,
    3. Hablitz JJ

    (2013) Regulation of epileptiform discharges in rat neocortex by HCN channels. J Neurophysiol 110, 1733–1743.
25. ↵
    1. Parsons CG,
    2. Stöffler A,
    3. Danysz W

    (2007) Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system--too little activation is bad, too much is even worse. Neuropharmacology 53, 699–723.
26. ↵
    1. Dichter MA,
    2. Ayala GF

    (1987) Cellular mechanism of epilepsy: A status report. Science 237, 157–164.
27. ↵
    1. Gilhotra N,
    2. Dhingra D

    (2011) Thymoquinone produced antianxiety-like effects in mice through modulation of GABA and NO levels. Pharmacol Rep 63, 660–669.
28. ↵
    1. Abdel-Zaher AO,
    2. Mostafa MG,
    3. Farghly HM,
    4. Hamdy MM,
    5. Omran GA,
    6. Al-Shaibani NK

    (2013) Inhibition of brain oxidative stress and inducible nitric oxide synthase expression by thymoquinone attenuates the development of morphine tolerance and dependence in mice. Eur J Pharmacol 702, 62–70.
29. ↵
    1. Ullah I,
    2. Ullah N,
    3. Naseer MI,
    4. Lee HY,
    5. Kim MO

    (2012) Neuroprotection with metformin and thymoquinone against ethanol-induced apoptotic neurodegeneration in prenatal rat cortical neurons. BMC Neurosci 13, 11.
30. ↵
    1. Lemos JR,
    2. Ortiz-Miranda SI,
    3. Cuadra AE,
    4. Velázquez-Marrero C,
    5. Custer EE,
    6. Dad T,
    7. et al.

    (2012) Modulation/physiology of calcium channel sub-types in neurosecretory terminals. Cell Calcium 51, 284–292.
31. ↵
    1. Gebhardt C,
    2. Breustedt JM,
    3. Nöldner M,
    4. Chatterjee SS,
    5. Heinemann U

    (2001) The antiepileptic drug losigamone decreases the persistent Na+current in rat hippocampal neurons. Brain Res 920, 27–31.
32. ↵
    1. Kovács Z1 CzurkóA,
    2. Kékesi KA,
    3. Juhász G

    (2011) The effect of intraperitoneally administered dimethyl sulfoxide on absence-like epileptic activity of freely moving WAG/Rij rats. J Neurosci Methods 197, 133–136.
33. ↵
    1. Carletti F,
    2. Ferraro G,
    3. Rizzo V,
    4. Cannizzaro C,
    5. Sardo P

    (2013) Antiepileptic effect of dimethyl sulfoxide in a rat model of temporal lobe epilepsy. Neurosci Lett 546, 31–35.