APOE Gene polymorphism among Jordanian Alzheimer’s patients with relation to lipid profile

Article Figures & Data

Table 1

Distribution of APOE genotypes frequencies in normal controls and AD patients.

Genotype	Control n=33	AD n=38	OR	CI	P-value	OR*	CI*	P-value*

	n (%)
ε3/ε3	29 (87.9)	23 (60.5)	Ref			Ref
ε2/ε3	1 (3.0)	4 (10.5)	5.0	0.53-48.3	0.18	4.8	0.48-48.6	0.18
ε2/ε2	0 (0)	0 (0)	†	†	†	†	†	†
ε2/ε4	2 (6.1)	0 (0)	†	†	†	†	†	†
ε3/ε4	1 (3.0)	10 (26.3)	12.6	1.5-105.8	0.0065	10.6	1.2-92.6	0.033
ε4/ε4	0 (0)	1 (2.6)	†	†	†	†	†	†

OR - odds ratio, CI - confidence interval, *values are adjusted to age and gender, ^†uncalculated due to empty cells, AD - Alzheimer disease, APOE - apolipoprotein E

Table 4

Lipid profile in AD patients with respect to e2 and e4 carriers and non-carriers.

Groups	ε2(+) n=4	ε2(-) n=34	P-value	P-value^*	ε4(+) n=11	ε4(-) n=27	P-value	P-value^*
TC	170±50	185.3±40.9	0.7	0.4	189.7±30.9	181.2±45.3	0.6	0.6
TG	147.2±28.9	162.9±119.9	0.5	0.8	125.7±33.0	175.8±131.2	0.4	0.2
LDL	98±39.7	104.5±32.4	0.9	0.8	111.0±22.3	100.9±36.0	0.6	0.99
HDL	47.3±16.4	43.4±11.9	0.8	0.4	46.5±11.1	42.8±12.8	0.6	0.7

↵* Values are adjusted to age and gender, only one patient showed e3(-) which is not enough to achieve sufficient statistical power. Thus, we only reported e2(±) and e4(±), the results are expressed as mean±standard deviation, mg/dL, AD - Alzheimer disease, TC - total cholesterol, TG - triglycerides, LDL - low density lipoprotein, HDL - high-density lipoprotein

Allele	Control n=33	AD n=38	OR	CI	P-value
Allele	n (%)		OR	CI	P-value
ε3	60 (90.9)	60 (78.9)	Ref	-	-
ε2	3 (4.5)	4 (5.3)	1.3	0.29-6.2	0.99
ε4	3 (4.5)	12 (15.8)	4.0	1.07-14.9	0.03