Article Figures & Data
Tables
1. Do you experience an urge to move the legs that is usually accompanied by an uncomfortable and unpleasant sensation in the legs? 2. Do you experience an urge to move your legs or an unpleasant sensation that begins or worsens during periods of rest or inactivity, such as lying or sitting? 3. The urge to move or unpleasant sensations are partially or totally relieved by movement, such as walking or stretching, at least as long as that activity continues. 4. Do you experience an urge to move your legs or an unpleasant sensation that is worse in the evening or at night than during the day or only occurs in the evening or night?. *All 4 criteria must be fulfilled for the diagnosis of restless leg to be made. **Adapted from Allen et al, official journal of the Movement Disorder Society. 2011;26(1):114-20. Characteristics IBD (N=218) Controls (N=211) P-value Mean age in years+-SD 30.90±1200 29.70±11.58 0.29 Female gender (%) 112 165 <0.001 Smoking status: 0.001 Never 161 170 0.07 Current cigarette 27 19 0.15 X cigarette 3 20 0.001 Current water pipe 17 10 0.15 X water pipe 2 0 0.15 Family history of IBD 17 19 0.68 Comorbidities: No chronic illness 178 172 0.36 DM 6 6 0.99 Hypertension 7 7 0.97 Rheumatoid arthritis 4 4 0.97 Vitamin B12 deficiency 7 12 0.22 Varicose veins 7 1 0.04 COPD 5 1 0.11 Hypothyroidism 4 7 0.34 Durations of RLS in years 1.36+-0.69 1.45+-0.79 0.20 Questions IBD(N=218) No IBD(N=211) P-value Do you experience an urge to move your legs that is usually accompanied or caused by uncomfortable and unpleasant sensations in the legs? 47 51 0.52 Do you experience an urge to move or an unpleasant sensation that begins or worsens during periods of rest or inactivity such as lying or sitting? 34 53 0.01 Do you experience an urge to move or unpleasant sensations that are partially or totally relieved by movement, such as by walking or stretching, at least as long as the activity continues? 41 60 0.02 Do you experience an urge to move or unpleasant sensations that are worse in the evening or at night than during the day or only occur in the evening or at night? 25 27 0.67 - Table 4
The study outcome comparing the odds ratio of IBD in patients with and without RLS.
IBD(Exposure) (N=218) Controls(No exposure) (N=211) TotalCohort (N=429) Statistics Restless leg syndrome (Case) 16 17 33 OR=0.90 No restless leg syndrome (Control) 202 194 396 95% CI=0.44 - 1.84 Total 218 211 429 p=0.78 - Table 5
Responses to the restless leg syndrome questionnaire comparing IBD patients and controls and a comparison of severity scores between the 2 cohorts.
Questionnaire items IBDN=218 No IBDN=211 P-value Mean±SD Overall, how would you rate The RLS discomfort in your legs or arms? 0.34±0.55 0.34±0.78 0.98 How would you rate the need to move around because of your RLS symptoms? 0.31±0.74 0.36±0.84 0.53 How severe was your sleep disturbance due to your RLS symptoms? 0.22±0.73 0.21±0.68 0.92 How severe was your tiredness or sleepiness during the day due to your RLS symptoms? 0.21±0.69 0.16±0.56 0.41 Overall, how severe was the impact of your RLS symptoms on your ability to carry out your daily affairs, for example carrying out a satisfactory family, home, social, school or work obligation? 0.27±0.96 0.16±0.52 0.14 How severe was your mood disturbance due to your RLS symptoms, for example feeling angry, depressed, sad, anxious or irritable? 0.28±0.79 0.26±0.74 0.75 Overall, how much relief of your RLS arm or leg discomfort did you get from moving around? 0.31±0.76 0.28±0.71 0.70 How often do you get RLS symptoms? 0.43±1.01 0.42±0.86 0.88 When you had RLS symptoms, how severe were they on average? 0.32±0.74 0.27±0.64 0.41 Total RLS severity score (RLSSS) 2.69±6.04 2.45±5.39 0.67 Severity category according to RLSSS n (%) P-value Mild RLS (Total RLSSS=1-10) 6 6 0.94 Moderate RLS (Total RLSSS=11-20) 6 7 0.80 Severe RLS (Total RLSSS=21-30) 4 3 0.82 Very severe RLS (Total RLSSS=31-40) 0 1 ----- Pearson chi2 (3)=1.1906 0.76 Total number of RLS cases 16 17 33 - Table 6
Predictors of restless leg syndrome and severe restless leg syndrome among IBD patients according to multiple logistic and linear regression analysis, respectively.
??? Odds ratio P-value 95% CI RLS Age in years 1.05 0.09 0.99-1.09 Sex 1.06 0.94 0.26-4.27 Cigarette smoker 0.50 0.56 0.05-5.10 X-cigarette smoker 0.81 0.86 0.08-7.92 DM 3.20 0.30 0.35-29.08 Rheumatoid Arthritis 7.72 0.12 0.60-99.95 Vitamin B12 deficiency 10.20 0.02 1.40-74.08 Varicose veins 5.01 0.11 0.68-36.92 COPD 5.47 0.16 0.51-59.00 RLSSS Coef P-value 95% CI Age in years 0.05 0.21 -0.03-0.12 Male gender -2.73 0.002 -4.47--0.98 Cigarette smoker -0.51 0.69 -3.02-2.01 X-cigarette smoker -0.47 0.74 -3.29-2.34 Water pipe smoker -1.61 0.39 -5.29-2.07 DM 5.74 0.03 0.60-10.87 Hypertension 0.83 0.73 -3.86-5.51 Rheumatoid Arthritis 5.48 0.06 -0.23-11.20 Vitamin B12 deficiency 3.46 0.12 -0.94-7.85 Varicose veins 0.96 0.66 -3.44-5.53 COPD 5.92 0.02 0.86-10.99 Hypothyroidism 0.64 0.83 -5.08-6 COPD - Chronic obstructive pulmonary disease
In this issue
Jump to section
Related Articles
Cited By...
- No citing articles found.