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Research ArticleOriginal Article
Open Access

Inflammatory bowel disease and restless leg syndrome

Mahmoud H. Mosli, Lujain M. Bukhari, Alya A. Khoja, Nuha A. Ashour, Hadeel R. Aljahdali, Ohood A. Khoja, Faris F. Alhejaili and Omar I. Saadah
Neurosciences Journal August 2020, 25 (4) 301-307; DOI: https://doi.org/10.17712/nsj.2020.4.20200021
Mahmoud H. Mosli
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS, MSc
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Lujain M. Bukhari
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Alya A. Khoja
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Nuha A. Ashour
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Hadeel R. Aljahdali
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Ohood A. Khoja
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Faris F. Alhejaili
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS, MSc
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Omar I. Saadah
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS, MRCP
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References

  1. ↵
    1. Repiso A,
    2. Alcántara M,
    3. Muñoz-Rosas C,
    4. Rodríguez-Merlo R,
    5. Pérez-Grueso M,
    6. Carrobles J,
    7. et al.
    (2006) Extraintestinal manifestations of Crohn’s disease: prevalence and related factors. Rev Esp Enferm Dig 98, 510.
  2. ↵
    1. Hoek PD,
    2. Smits MG,
    3. de Roos NM,
    4. Rijsman RM,
    5. Witteman BJ
    (2015) Increased prevalence of restless legs syndrome in patients with Crohn’s disease. Eur J Gastroenterol Hepatol 27, 951–955.
  3. ↵
    1. Guagnozzi D,
    2. Lucendo AJ
    (2014) Anemia in inflammatory bowel disease: A neglected issue with relevant effects. World J Gastroenterol 20, 3542–3551.
  4. ↵
    1. Weinstock LB,
    2. Walters AS
    (2011) Restless legs syndrome is associated with irritable bowel syndrome and small intestinal bacterial overgrowth. Sleep Med 12, 610–613.
  5. ↵
    1. Allen RP,
    2. Earley CJ
    (2007) The role of iron in restless legs syndrome. Mov Disord 22, S440–S448.
  6. ↵
    1. Allen RP,
    2. Auerbach S,
    3. Bahrain H,
    4. Auerbach M,
    5. Earley CJ
    (2013) The prevalence and impact of restless legs syndrome on patients with iron deficiency anemia. Am J Hematol 88, 261–264.
  7. ↵
    1. Trenkwalder C,
    2. Allen R,
    3. Hogl B,
    4. Paulus W,
    5. Winkelmann J
    (2016) Restless legs syndrome associated with major diseases: A systematic review and new concept. Neurology 86, 1336–1343.
  8. ↵
    1. Chen NH,
    2. Chuang LP,
    3. Yang CT,
    4. Kushida CA,
    5. Hsu SC,
    6. Wang PC,
    7. et al.
    (2010) The prevalence of restless legs syndrome in Taiwanese adults. Psychiatry Clin Neurosci 64, 170–178.
  9. ↵
    1. Takahara I,
    2. Takeshima F,
    3. Ichikawa T,
    4. Matsuzaki T,
    5. Shibata H,
    6. Miuma S,
    7. et al.
    (2017) Prevalence of Restless Legs Syndrome in Patients with Inflammatory Bowel Disease. Dig Dis Sci 62, 761–767.
  10. ↵
    1. Alharbi O,
    2. Azzam N,
    3. Almadi M,
    4. Angkaya F,
    5. Sadaf N,
    6. Aljebreen A,
    7. et al.
    (2016) P-058 YI Prevalence of Restless Leg Syndrome Among Patients Suffering from Inflammatory Bowel Disease in Saudi Arabia. Inflammatory Bowel Diseases 22, S28.
  11. ↵
    1. Ohayon MM,
    2. O’Hara R,
    3. Vitiello MV
    (2012) Epidemiology of Restless Legs Syndrome: A Synthesis of the Literature. Sleep Med Rev 16, 283–295.
  12. ↵
    1. Manconi M,
    2. Ulfberg J,
    3. Berger K,
    4. Ghorayeb I,
    5. Wesstrom J,
    6. Fulda S,
    7. et al.
    (2012) When gender matters: restless legs syndrome. Report of the “RLS and woman” workshop endorsed by the European RLS Study Group. Sleep Med Rev 16, 297–307.
  13. ↵
    1. Allen RP,
    2. Walters AS,
    3. Montplaisir J,
    4. Hening W,
    5. Myers A,
    6. Bell TJ,
    7. et al.
    (2005) Restless legs syndrome prevalence and impact: REST general population study. Arch Intern Med 165, 1286–1292.
  14. ↵
    1. Allen RP,
    2. Bharmal M,
    3. Calloway M
    (2011) Prevalence and disease burden of primary restless legs syndrome: results of a general population survey in the United States. Mov Disord 26, 114–120.
  15. ↵
    1. Wali SO,
    2. Abaalkhail B
    (2015) Prevalence of restless legs syndrome and associated risk factors among middle-aged Saudi population. Ann Thorac Med 10, 193–198.
  16. ↵
    1. Cho SJ,
    2. Hong JP,
    3. Hahm BJ,
    4. Jeon HJ,
    5. Chang SM,
    6. Cho MJ,
    7. et al.
    (2009) Restless legs syndrome in a community sample of Korean adults: prevalence, impact on quality of life, and association with DSM-IV psychiatric disorders. Sleep 32, 1069–1076.
    1. Ohayon MM,
    2. Roth T
    (2002) Prevalence of restless legs syndrome and periodic limb movement disorder in the general population. J Psychosom Res 53, 547–54.
  17. ↵
    1. Sevim S,
    2. Dogu O,
    3. Camdeviren H,
    4. Bugdayci R,
    5. Sasmaz T,
    6. Kaleagasi H,
    7. et al.
    (2003) Unexpectedly low prevalence and unusual characteristics of RLS in Mersin, Turkey. Neurology 61, 1562–1569.
  18. ↵
    1. Akin S,
    2. Boluk C,
    3. Turk Boru U,
    4. Tasdemir M,
    5. Gezer T,
    6. Sahbaz FG,
    7. et al.
    (2019) Restless legs syndrome in type 2 diabetes mellitus. Prim Care Diabetes 13, 87–91.
  19. ↵
    1. Li LH,
    2. Chen HB,
    3. Zhang LP,
    4. Wang ZW,
    5. Wang CP
    (2012) A community-based investigation on restless legs syndrome in a town in China. Sleep Med 13, 342–345.
  20. ↵
    1. Tasdemir M,
    2. Erdogan H,
    3. Boru UT,
    4. Dilaver E,
    5. Kumas A
    (2010) Epidemiology of restless legs syndrome in Turkish adults on the western Black Sea coast of Turkey: A door-to-door study in a rural area. Sleep Med 11, 82–86.
  21. ↵
    1. Ohayon MM,
    2. O’Hara R,
    3. Vitiello MV
    (2012) Epidemiology of restless legs syndrome: a synthesis of the literature. Sleep Med Rev 16, 283–295.
  22. ↵
    1. O’Keeffe ST,
    2. Noel J,
    3. Lavan JN
    (1993) Restless legs syndrome in the elderly. Postgrad Med J 69, 701–703.
  23. ↵
    1. Becker J,
    2. Berger F,
    3. Schindlbeck KA,
    4. Poddubnyy D,
    5. Koch PM,
    6. Preiss JC,
    7. et al.
    (2018) Restless legs syndrome is a relevant comorbidity in patients with inflammatory bowel disease. Int J Colorectal Dis 33, 955–962.
  24. ↵
    1. Cho YW,
    2. Shin WC,
    3. Yun CH,
    4. Hong SB,
    5. Kim JH,
    6. Allen RP,
    7. et al.
    (2008) Epidemiology of restless legs syndrome in Korean adults. Sleep 31, 219–223.
  25. ↵
    1. Tison F,
    2. Crochard A,
    3. Leger D,
    4. Bouee S,
    5. Lainey E,
    6. El Hasnaoui A
    (2005) Epidemiology of restless legs syndrome in French adults: a nationwide survey: the INSTANT Study. Neurology 65, 239–246.
  26. ↵
    1. Erer S,
    2. Karli N,
    3. Zarifoglu M,
    4. Ozcakir A,
    5. Yildiz D
    (2009) The prevalence and clinical features of restless legs syndrome: a door to door population study in Orhangazi, Bursa in Turkey. Neurol India 57, 729–733.
  27. ↵
    1. Ulfberg J,
    2. Bjorvatn B,
    3. Leissner L,
    4. Gyring J,
    5. Karlsborg M,
    6. Regeur L,
    7. et al.
    (2007) Comorbidity in restless legs syndrome among a sample of Swedish adults. Sleep Med 8, 768–772.
  28. ↵
    1. Bjorvatn B,
    2. Leissner L,
    3. Ulfberg J,
    4. Gyring J,
    5. Karlsborg M,
    6. Regeur L,
    7. et al.
    (2005) Prevalence, severity and risk factors of restless legs syndrome in the general adult population in two Scandinavian countries. Sleep Med 6, 307–312.
  29. ↵
    1. Ekbom K,
    2. Ulfberg J
    (2009) Restless legs syndrome. J Intern Med 266, 419–431.
  30. ↵
    1. Hadjigeorgiou GM,
    2. Stefanidis I,
    3. Dardiotis E,
    4. Aggellakis K,
    5. Sakkas GK,
    6. Xiromerisiou G,
    7. et al.
    (2007) Low RLS prevalence and awareness in central Greece: an epidemiological survey. Eur J Neurol 14, 1275–1280.
  31. ↵
    1. Gupta R,
    2. Ulfberg J,
    3. Allen RP,
    4. Goel D
    (2017) High prevalence of restless legs syndrome/Willis Ekbom Disease (RLS/WED) among people living at high altitude in the Indian Himalaya. Sleep Med 35, 7–11.
  32. ↵
    1. Sundaresan S,
    2. Migden MR,
    3. Silapunt S
    (2019) Treatment of Leg Veins for Restless Leg Syndrome: A Retrospective Review. Cureus 11, e4368.
  33. ↵
    1. Hayes CA,
    2. Kingsley JR,
    3. Hamby KR,
    4. Carlow J
    (2008) The effect of endovenous laser ablation on restless legs syndrome. Phlebology 23, 112–117.
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Inflammatory bowel disease and restless leg syndrome
Mahmoud H. Mosli, Lujain M. Bukhari, Alya A. Khoja, Nuha A. Ashour, Hadeel R. Aljahdali, Ohood A. Khoja, Faris F. Alhejaili, Omar I. Saadah
Neurosciences Journal Aug 2020, 25 (4) 301-307; DOI: 10.17712/nsj.2020.4.20200021

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Inflammatory bowel disease and restless leg syndrome
Mahmoud H. Mosli, Lujain M. Bukhari, Alya A. Khoja, Nuha A. Ashour, Hadeel R. Aljahdali, Ohood A. Khoja, Faris F. Alhejaili, Omar I. Saadah
Neurosciences Journal Aug 2020, 25 (4) 301-307; DOI: 10.17712/nsj.2020.4.20200021
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