The response patterns of infantile spasms to treatments in 156 patients: Hormonal therapy with intravenous synthetic ACTH appears promising

Muhammad T. Alrifai; Ahmad R. Al-Rumayyan; Waleed A. Al-Tuwaijri; Duaa M. Baarmah; Safiyyah A. Asiri; Ahmad H. Bali; Muatassem A. Alsadhan; Shaden H. Alsugheir

doi:10.17712/nsj.2022.1.20210116

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The response patterns of infantile spasms to treatments in 156 patients

Hormonal therapy with intravenous synthetic ACTH appears promising

Muhammad T. Alrifai, Ahmad R. Al-Rumayyan, Waleed A. Al-Tuwaijri, Duaa M. Baarmah, Safiyyah A. Asiri, Ahmad H. Bali, Muatassem A. Alsadhan and Shaden H. Alsugheir

Neurosciences Journal January 2022, 27 (1) 40-44; DOI: https://doi.org/10.17712/nsj.2022.1.20210116

Muhammad T. Alrifai

From the Department of Pediatrics (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Bali), Neurology Division, King Abdullah Specialist Children’s Hospital, King Abdulaziz Medical City, from the College of Medicine (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali, Alsadhan, Alsugheir), King Saud bin Abdulaziz University for Health Sciences, and from King Abdullah International Medical Research Center (Alrifai, Al-Rumayyan, Al-Tuwaijri, Baarmah, Asiri, Bali), Riyadh, Kingdom of Saudi Arabia.

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For correspondence: [email protected]

Ahmad R. Al-Rumayyan

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Waleed A. Al-Tuwaijri

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Duaa M. Baarmah

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Safiyyah A. Asiri

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Ahmad H. Bali

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Muatassem A. Alsadhan

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Shaden H. Alsugheir

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Table 1

- Comparison of responders to treatment vs non-responders groups.

	Responders n=72	Non-responders n=84	P-value
	n (%)
Male gender	43(60)	44(52)	0.35
Age(month)
Mean (SD)	9.7(7)	9.6(6.6)	0.44
Etiology
Median	7	8
Cryptogenic	22(31)	20(24)	0.34
Symptomatic	50(69)	64(76)
EEG
Typical hypsarrhythmia	26(36)	20(24)	0.09
Atypical hypsarrhythmia	46(64)	64(76)
Outcome
Fair	14(19)	0(0)	0.000
poor	58(81)	84(100)
Epilepsy at 2 years	26/50(52)	50/57(88)	0.000

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The response patterns of infantile spasms to treatments in 156 patients

Muhammad T. Alrifai, Ahmad R. Al-Rumayyan, Waleed A. Al-Tuwaijri, Duaa M. Baarmah, Safiyyah A. Asiri, Ahmad H. Bali, Muatassem A. Alsadhan, Shaden H. Alsugheir

Neurosciences Journal Jan 2022, 27 (1) 40-44; DOI: 10.17712/nsj.2022.1.20210116

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The response patterns of infantile spasms to treatments in 156 patients

Muhammad T. Alrifai, Ahmad R. Al-Rumayyan, Waleed A. Al-Tuwaijri, Duaa M. Baarmah, Safiyyah A. Asiri, Ahmad H. Bali, Muatassem A. Alsadhan, Shaden H. Alsugheir

Neurosciences Journal Jan 2022, 27 (1) 40-44; DOI: 10.17712/nsj.2022.1.20210116

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