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Research ArticleOriginal Article
Open Access

Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case–control study

Osama A. Al-Wutayd, Ashri G. Mohamed, Jameelah A. Saeedi, Hessa S. Alotaibi and Mohammed A. Al Jumah
Neurosciences Journal April 2022, 27 (2) 87-93; DOI: https://doi.org/10.17712/nsj.2022.2.20210121
Osama A. Al-Wutayd
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
MD
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Ashri G. Mohamed
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
PHD
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Jameelah A. Saeedi
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
MD
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Hessa S. Alotaibi
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
MD
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Mohammed A. Al Jumah
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
MD, FRCPC
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Article Figures & Data

Tables

    • View popup
    Table 1

    - Mean body mass index for each body silhouette of male and female participants at the time of the study.

    Gender /GroupBody silhouette
    123456789
    Male
    MS patients23.921.723.425.726.931.231.637.244.7
    ControlsN/A22.323.126.726.530.330.938.4N/A
    Female
    MS patients19.72123.525.727.730.735.339.933.8
    Controls19.521.123.726.829.932.935.938.138.5

    All values are means, MS - multiple sclerosis, N/A - not available

      • View popup
      Table 2

      - Unadjusted analysis of the association between body size during different school levels and the odds of developing multiple sclerosis.

      School level /Body sizeMS patientsControlsCrude OR (95% CI)P-value
      n=307n=307
      n (%)
      Primary school
      199 (32)117 (38)0.67 (0.40–1.13)0.134
      283 (27)92 (30)0.72 (0.42–1.22)0.223
      344 (14)35 (11)Reference 
      431 (10)46 (15)0.54 (0.28–1.01)0.055
      523 (8)13 (4)1.41 (0.63–3.17)0.410
      6–927 (9)4 (1)5.37 (1.72–16.79)0.004
      Intermediate school
      146 (15)77 (25)0.70 (0.40–1.21)0.199
      294 (31)93 (30)1.18 (0.71–1.95)0.520
      342 (14)49 (16)Reference 
      446 (15)59 (19)0.91 (0.52–1.60)0.742
      540 (13)17 (6)2.75 (1.36–5.54)0.005
      6–939 (13)12 (4)3.79 (1.76–8.17)0.001
      Secondary school
      130 (10)48 (16)0.94 (0.53–1.67)0.827
      280 (26)66 (22)1.80 (1.11–2.90)0.018
      350 (16)77 (25)Reference 
      462 (20)65 (21)1.41 (0.86–2.32)0.177
      536 (12)33 (11)1.64 (0.91–2.96)0.103
      6–949 (16)18 (6)4.08 (2.14–7.81)<0.001
      University
      132 (11)37 (12)1.04 (0.57–1.89)0.895
      264 (21)55 (18)1.38 (0.83–2.29)0.219
      354 (18)67 (22)Reference 
      452 (17)77 (25)0.80 (0.49–1.33)0.392
      552 (17)44 (15)1.42 (0.83–2.44)0.201
      6–948 (16)24 (8)2.41 (1.31–4.43)0.005

      MS - multiple sclerosis, OR - odds ratio, CI - confidence interval

        • View popup
        Table 3

        - Multivariable analysis of the association between body size during different school levels and the odds of developing multiple sclerosis.

        School level /Body sizeAll*Females
        Adjusted OR (95% CI)P-valueAdjusted OR (95% CI)P-value
        Primary school
        11.12 (0.55–2.26)0.7621.70 (0.75–3.88)0.206
        20.85 (0.45–1.60)0.6141.18 (0.56–2.49)0.671
        3Reference Reference 
        40.36 (0.17–0.76)0.0070.41 (0.18–0.95)0.039
        50.51 (0.18–1.45)0.2070.96 (0.26–3.51)0.951
        6–91.57 (0.41–6.05)0.5161.04 (0.24–4.60)0.958
        Intermediate school
        10.39 (0.17–0.90)0.0290.25 (0.09–0.66)0.005
        20.87 (0.46–1.65)0.6750.46 (0.21–0.98)0.045
        3Reference Reference 
        41.07 (0.54–2.14)0.8450.87 (0.39–1.95)0.740
        53.75 (1.41–10)0.0083.04 (1.01–9.11)0.047
        6–93.75 (1.10–12.78)0.0354.59 (1.01–20.86)0.048
        Secondary school
        10.82 (0.32–2.16)0.6940.87 (0.30–2.48)0.788
        21.68 (0.90–3.12)0.1011.79 (0.88–3.63)0.109
        3Reference Reference 
        41.40 (0.73–2.68)0.3111.61 (0.73–3.55)0.242
        51.23 (0.49–3.07)0.6561.61 (0.53–4.87)0.400
        6–91.49 (0.45–4.90)0.5151.44 (0.34–6.09)0.617
        University
        11.92 (0.80–4.60)0.1441.69 (0.67–4.26)0.269
        21.31 (0.72–2.39)0.3781.56 (0.80–3.05)0.194
        3Reference Reference 
        40.60 (0.33–1.07)0.0840.68 (0.33–1.40)0.291
        51.03 (0.51–2.09)0.9300.92 (0.39–2.16)0.851
        6–90.97 (0.37–2.57)0.9500.79 (0.24–2.58)0.696

        *Adjusted for age, gender, and hospital, OR - odds ratio, CI - confidence interval

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        Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case–control study
        Osama A. Al-Wutayd, Ashri G. Mohamed, Jameelah A. Saeedi, Hessa S. Alotaibi, Mohammed A. Al Jumah
        Neurosciences Journal Apr 2022, 27 (2) 87-93; DOI: 10.17712/nsj.2022.2.20210121

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        Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case–control study
        Osama A. Al-Wutayd, Ashri G. Mohamed, Jameelah A. Saeedi, Hessa S. Alotaibi, Mohammed A. Al Jumah
        Neurosciences Journal Apr 2022, 27 (2) 87-93; DOI: 10.17712/nsj.2022.2.20210121
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