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Research ArticleOriginal Article
Open Access

Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case–control study

Osama A. Al-Wutayd, Ashri G. Mohamed, Jameelah A. Saeedi, Hessa S. Alotaibi and Mohammed A. Al Jumah
Neurosciences Journal April 2022, 27 (2) 87-93; DOI: https://doi.org/10.17712/nsj.2022.2.20210121
Osama A. Al-Wutayd
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
MD
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Ashri G. Mohamed
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
PHD
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Jameelah A. Saeedi
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
MD
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Hessa S. Alotaibi
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
MD
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Mohammed A. Al Jumah
From the Department of Family and Community Medicine (Al-Wutayd), Unaizah College of Medicine and Medical Sciences, Qassim University, Unaizah, Department of Family and Community Medicine Department (Mohamed), King Khalid University Hospital, King Abdullah bin Abdul-Aziz University Hospital (Saeedi), Princess Nora bint Abdulrahman University, King Fahad Medical City (Al Jumah), Ministry of Health, King Abdullah International Medical Research Center-King Saud bin Abdulaziz University for Health Sciences (Al Jumah), Riyadh, and from King Fahad General Hospital (Alotaibi), Ministry of Health, Jedda, Kingdom of Saudi Arabia.
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References

  1. 1.↵
    1. Dobson R,
    2. Giovannoni G.
    Multiple sclerosis - a review. Eur J Neurol 2019; 26: 27–40.
    OpenUrl
  2. 2.↵
    1. Al Jumah M,
    2. Kojan S,
    3. Al Shehri AM,
    4. Al Balwi M,
    5. Al Abdulkarim I,
    6. Masuadi EM, et al.
    HLA class II polymorphism in Saudi patients with multiple sclerosis. HLA 2018; 91: 17–22.
    OpenUrl
  3. 3.
    1. Al Wutayd O,
    2. Mohamed AG,
    3. Saeedi J,
    4. Al Otaibi H,
    5. Al Jumah M.
    Environmental exposures and the risk of multiple sclerosis in Saudi Arabia. BMC Neurol 2018; 18: 86.
    OpenUrl
  4. 4.
    1. Thompson AJ,
    2. Baranzini SE,
    3. Geurts J,
    4. Hemmer B
    , Ciccarelli O. Multiple sclerosis. Lancet 2018; 391: 1622–1636.
    OpenUrlCrossRefPubMed
  5. 5.
    1. Al Wutayd O.
    Association of infections with multiple sclerosis in Gulf Cooperation Council countries: a review. J Int Med Res 2020; 48: 300060519884151.
    OpenUrl
  6. 6.↵
    1. Olsson T,
    2. Barcellos LF,
    3. Alfredsson L.
    Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis. Nat Rev Neurol 2017; 13: 25–36.
    OpenUrlCrossRefPubMed
  7. 7.↵
    1. Hedstrom AK,
    2. Olsson T,
    3. Alfredsson L.
    High body mass index before age 20 is associated with increased risk for multiple sclerosis in both men and women. Mult Scler 2012; 18: 1334–1336.
    OpenUrl
  8. 8.↵
    1. Wesnes K,
    2. Riise T,
    3. Casetta I,
    4. Drulovic J,
    5. Granieri E,
    6. Holmoy T, et al.
    Body size and the risk of multiple sclerosis in Norway and Italy: the EnvIMS study. Mult Scler 2015; 21: 388–395.
    OpenUrlCrossRefPubMed
  9. 9.↵
    1. AlJumah M,
    2. Bunyan R,
    3. Al Otaibi H,
    4. Al Towaijri G,
    5. Karim A,
    6. Al Malik Y, et al.
    Rising prevalence of multiple sclerosis in Saudi Arabia, a descriptive study. BMC Neurol 2020; 20: 49.
    OpenUrl
  10. 10.↵
    1. Langer-Gould A,
    2. Brara SM,
    3. Beaber BE,
    4. Koebnick C.
    Childhood obesity and risk of pediatric multiple sclerosis and clinically isolated syndrome. Neurology 2013; 80: 548–552.
    OpenUrlCrossRefPubMed
  11. 11.↵
    1. Aa Høglund RA,
    2. Meyer HE,
    3. Stigum H,
    4. Torkildsen Ø,
    5. Nina Grytten N,
    6. Holmøy T, et al.
    Association of Body Mass Index in Adolescence and Young Adulthood and Long-term Risk of Multiple Sclerosis: A Population-Based Study. Neurology 2021; 97: e2253–e2261.
    OpenUrlCrossRefPubMed
  12. 12.↵
    1. Munger KL,
    2. Bentzen J,
    3. Laursen B,
    4. Stenager E,
    5. Koch-Henriksen N,
    6. Sorensen TI, et al.
    Childhood body mass index and multiple sclerosis risk: a long-term cohort study. Mult Scler 2013; 19: 1323–1329.
    OpenUrlCrossRefPubMed
  13. 13.↵
    1. Halawani AT,
    2. Zeidan ZA,
    3. Kareem AM,
    4. Alharthi AA,
    5. Almalki H.A.
    Sociodemographic, environmental and lifestyle risk factors for multiple sclerosis development in the Western region of Saudi Arabia: a matched case control study. Saudi Med J 2018; 39: 808–814.
    OpenUrlAbstract/FREE Full Text
  14. 14.↵
    1. Munger KL,
    2. Chitnis T,
    3. Ascherio A.
    Body size and risk of MS in two cohorts of US women. Neurology 2009; 73: 1543–1550.
    OpenUrlCrossRefPubMed
  15. 15.↵
    1. Hedström AK,
    2. Bomfim IL,
    3. Barcellos L,
    4. Gianfrancesco M,
    5. Schaefer C,
    6. Kockum I,
    7. Olsson T, et al.
    Interaction between adolescent obesity and HLA risk genes in the etiology of multiple sclerosis. Neurology 2014; 82: 865–872.
    OpenUrlCrossRefPubMed
  16. 16.↵
    1. Al Jumah M,
    2. Kojan S,
    3. Al Shehri AM,
    4. Al Balwi M,
    5. Al Abdulkarim I,
    6. Masuadi EM, et al.
    HLA class II polymorphism in Saudi patients with multiple sclerosis. HLA 2018; 91: 17–22.
    OpenUrl
  17. 17.↵
    1. Hedström AK,
    2. Bomfim I,
    3. Hillert J,
    4. Olsson T,
    5. Alfredsson L.
    Obesity interacts with infectious mononucleosis in risk of multiple sclerosis. Eur J Neurol 2015; 22: e578–e538.
    OpenUrl
  18. 18.↵
    1. Manouchehrinia A,
    2. Hedström AK,
    3. Alfredsson L,
    4. Olsson T,
    5. Hillert J,
    6. Ramanujam R.
    Association of pre-disease body mass index with multiple sclerosis prognosis. Front Neurol 2018; 9: 232.
    OpenUrl
  19. 19.↵
    1. Abbas MA.
    Physiological functions of Vitamin D in adipose tissue. J Steroid Biochem Mol Biol 2017; 165: 369–381.
    OpenUrlCrossRefPubMed
  20. 20.↵
    1. Ruiz-Ojeda FJ,
    2. Anguita-Ruiz A,
    3. Leis R,
    4. Aguilera CM.
    Genetic Factors and Molecular Mechanisms of Vitamin D and Obesity Relationship. Ann Nutr Metab 2018; 73: 89–99.
    OpenUrl
  21. 21.↵
    1. Goldner WS,
    2. Stoner JA,
    3. Thompson J,
    4. Taylor K,
    5. Larson L,
    6. Erickson J, et al.
    Prevalence of vitamin D insufficiency and deficiency in morbidly obese patients: a comparison with non-obese controls. Obes Surg 2008; 18: 145–150.
    OpenUrlCrossRefPubMed
  22. 22.↵
    1. Konradsen S,
    2. Ag H,
    3. Lindberg F,
    4. Hexeberg S,
    5. Jorde R.
    Serum 1,25-dihydroxy vitamin D is inversely associated with body mass index. Eur J Nutr 2008; 47: 87–91.
    OpenUrlCrossRefPubMedWeb of Science
  23. 23.↵
    1. Ellulu MS,
    2. Patimah I,
    3. Khaza’ai H,
    4. Rahmat A,
    5. Abed Y.
    Obesity and inflammation: the linking mechanism and the complications. Arch Med Sci 2017; 13: 851–863.
    OpenUrlCrossRefPubMed
  24. 24.
    1. Shindy S,
    2. Cho KW.
    Adipose tissue dendritic cells: critical regulators of obesity-induced inflammation and insulin resistance. Int J Mol Sci 2021; 22: 8666.
    OpenUrl
  25. 25.↵
    1. Kumthekar, A,
    2. Ogdie A.
    Obesity and Psoriatic Arthritis: A Narrative Review. Rheumatol Ther 2020; 7: 447–456.
    OpenUrl
  26. 26.↵
    1. Guerrero-García JD,
    2. Carrera-Quintanar L,
    3. López-Roa RI,
    4. Márquez-Aguirre AL,
    5. Rojas-Mayorquín AE,
    6. Ortuño-Sahagún D.
    Multiple sclerosis and obesity: possible roles of adipokines. Mediators Inflamm 2016; 2016: 4036232.
    OpenUrl
  27. 27.↵
    1. Asghar A,
    2. Sheikh N.
    Role of immune cells in obesity induced low grade inflammation and insulin resistance. Cell Immunol 2017; 315: 18–26.
    OpenUrlCrossRefPubMed
  28. 28.↵
    1. Al-Hussaini A,
    2. Bashir MS,
    3. Khormi M,
    4. AlTuraiki M,
    5. Alkhamis W,
    6. Alrajhi M, et al.
    Overweight and obesity among Saudi children and adolescents: Where do we stand today? Saudi J Gastroenterol 2019; 25: 229–235.
    OpenUrlPubMed
  29. 29.↵
    1. Cortese M,
    2. Riise T,
    3. Bjørnevik K,
    4. Myhr KM.
    Multiple Sclerosis Conscript Service Database Study Group. Body size and physical exercise, and the risk of multiple sclerosis. Mult Scler J 2018; 24: 270–278.
    OpenUrl
  30. 30.↵
    1. Lønnebotn M,
    2. Svanes C,
    3. Igland J,
    4. Franklin KA,
    5. Accordini S,
    6. Benediktsdo´ttir B, et al.
    Body silhouettes as a tool to reflect obesity in the past. PloS one 2018: e0195697.
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Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case–control study
Osama A. Al-Wutayd, Ashri G. Mohamed, Jameelah A. Saeedi, Hessa S. Alotaibi, Mohammed A. Al Jumah
Neurosciences Journal Apr 2022, 27 (2) 87-93; DOI: 10.17712/nsj.2022.2.20210121

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Association between obesity during different age periods and multiple sclerosis in Saudi Arabia: A multicenter case–control study
Osama A. Al-Wutayd, Ashri G. Mohamed, Jameelah A. Saeedi, Hessa S. Alotaibi, Mohammed A. Al Jumah
Neurosciences Journal Apr 2022, 27 (2) 87-93; DOI: 10.17712/nsj.2022.2.20210121
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