Research ArticleOriginal Article
Open Access

Vagus nerve stimulation in medically refractory epilepsy: Adverse effects and clinical correlates

Khaled A. Alshehri, Shaima H. Abuhulayqah, Mohammed A. Asiry and Suad A. Alyamani
Neurosciences Journal January 2024, 29 (1) 10-17; DOI: https://doi.org/10.17712/nsj.2024.1.20230006

References

  1. 1.↵
    1. Wheless JW,
    2. Gienapp AJ,
    3. Ryvlin P.
    Vagus nerve stimulation (VNS) therapy update. Epilepsy Behav 2018; 88S: 2–10.
    OpenUrlCrossRefPubMed
  2. 2.↵
    1. Kwan P,
    2. Brodie MJ.
    Early identification of refractory epilepsy. N Engl J Med 2000; 342: 314–319.
    OpenUrlCrossRefPubMedWeb of Science
  3. 3.↵
    1. Mohanraj R,
    2. Brodie MJ.
    Diagnosing refractory epilepsy: response to sequential treatment schedules. Eur J Neurol 2006; 13: 277–282.
    OpenUrlCrossRefPubMedWeb of Science
  4. 4.↵
    1. Ben-Menachem E,
    2. Mañon-Espaillat R,
    3. Ristanovic R,
    4. Wilder BJ,
    5. Stefan H,
    6. Mirza W, et al.
    First International Vagus Nerve Stimulation Study Group. Vagus nerve stimulation for treatment of partial seizures: 1. A controlled study of effect on seizures. Epilepsia 1994; 35: 616–626.
    OpenUrlCrossRefPubMedWeb of Science
  5. 5.↵
    1. Handforth A,
    2. DeGiorgio CM,
    3. Schachter SC,
    4. Uthman BM,
    5. Naritoku DK,
    6. Tecoma ES, et al.
    Vagus nerve stimulation therapy for partial-onset seizures: a randomized active-control trial. Neurology 1998; 51: 48–55.
    OpenUrlCrossRefPubMed
  6. 6.↵
    1. Ryvlin P,
    2. Gilliam FG,
    3. Nguyen DK,
    4. Colicchio G,
    5. Iudice A,
    6. Tinuper P, et al.
    The long-term effect of vagus nerve stimulation on quality of life in patients with pharmacoresistant focal epilepsy: the PuLsE (Open Prospective Randomized Long-term Effectiveness) trial [Erratum in: Epilepsia 2014; 55; 9: 1476. Erratum in: Epilepsia 2015; 56: 983. Epilepsia 2014; 55: 893–900.
  7. 7.↵
    1. González HF,
    2. Yengo-Kahn A,
    3. Englot DJ.
    Vagus Nerve Stimulation for the Treatment of Epilepsy. Neurosurg Clin N Am 2019; 30: 219–230.
    OpenUrl
  8. 8.↵
    1. Parhizgar F,
    2. Nugent K,
    3. Raj R.
    Obstructive sleep apnea and respiratory complications associated with vagus nerve stimulators. J Clin Sleep Med 2011; 7: 401–407.
    OpenUrlPubMed
  9. 9.↵
    1. Héberlé C,
    2. Berquin P,
    3. Larnicol N,
    4. Wallois F.
    Vagus nerve stimulation in a case of epilepsy with CSWSS: respiratory side effects during sleep. Epilepsia 2002; 43: 1268–1270.
    OpenUrlPubMed
  10. 10.↵
    1. Suller Marti A,
    2. Mirsattari SM,
    3. MacDougall K,
    4. Steven DA,
    5. Parrent A,
    6. de Ribaupierre S, et al.
    Vagus nerve stimulation in patients with therapy-resistant generalized epilepsy. Epilepsy Behav 2020; 111: 107253.
    OpenUrl
  11. 11.↵
    1. Zambrelli E,
    2. Saibene AM,
    3. Furia F,
    4. Chiesa V,
    5. Vignoli A,
    6. Pipolo C, et al.
    Laryngeal motility alteration: A missing link between sleep apnea and vagus nerve stimulation for epilepsy. Epilepsia 2016; 57: e24–e27.
    OpenUrlCrossRefPubMed
  12. 12.
    1. Castellani L,
    2. Chiesa V,
    3. Maccari A,
    4. Fuccillo E,
    5. Canevini MP,
    6. Felisati G, et al.
    Pharyngolaryngeal spasm-induced dysphagia in an epileptic patient undergoing vagus nerve stimulation therapy. Clin Case Rep 2020; 8: 858–861.
    OpenUrl
  13. 13.
    1. Marzec M,
    2. Edwards J,
    3. Sagher O,
    4. Fromes G,
    5. Malow BA.
    Effects of vagus nerve stimulation on sleep-related breathing in epilepsy patients. Epilepsia 2003; 44: 930–935.
    OpenUrlPubMedWeb of Science
  14. 14.↵
    1. Hsieh T,
    2. Chen M,
    3. McAfee A,
    4. Kifle Y.
    Sleep-related breathing disorder in children with vagal nerve stimulators. Pediatr Neurol 2008; 38: 99–103.
    OpenUrlPubMedWeb of Science
  15. 15.↵
    1. Kwan P,
    2. Arzimanoglou A,
    3. Berg AT,
    4. Brodie MJ,
    5. Allen Hauser W,
    6. Mathern G, et al.
    Definition of drug resistant epilepsy: consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies [Erratum in: Epilepsia 2010; 51: 1922. Epilepsia 2010; 51: 1069–1077.
  16. 16.↵
    The Vagus Nerve Stimulation Study Group. A randomized controlled trial of chronic vagus nerve stimulation for treatment of medically intractable seizures. Neurology 1995; 45: 224–230.
    OpenUrlCrossRefPubMed
  17. 17.↵
    1. De Herdt V,
    2. Boon P,
    3. Ceulemans B,
    4. Hauman H,
    5. Lagae L,
    6. Legros B, et al.
    Vagus nerve stimulation for refractory epilepsy: a Belgian multicenter study. Eur J Paediatr Neurol 2007; 11: 261–269.
    OpenUrlPubMed
  18. 18.↵
    1. Batson S,
    2. Shankar R,
    3. Conry J,
    4. Boggs J,
    5. Radtke R,
    6. Mitchell S, et al.
    Efficacy and safety of VNS therapy or continued medication management for treatment of adults with drug-resistant epilepsy: systematic review and meta-analysis. J Neurol 2022; 269: 2874–2891.
    OpenUrl
  19. 19.↵
    1. Englot DJ,
    2. Hassnain KH,
    3. Rolston JD,
    4. Harward SC,
    5. Sinha SR,
    6. Haglund MM.
    Quality-of-life metrics with vagus nerve stimulation for epilepsy from provider survey data. Epilepsy Behav 2017; 66: 4–9.
    OpenUrl
  20. 20.↵
    1. Kalilani L,
    2. Sun X,
    3. Pelgrims B,
    4. Noack-Rink M,
    5. Villanueva V.
    The epidemiology of drug-resistant epilepsy: A systematic review and meta-analysis. Epilepsia 2018; 59: 2179–2193.
    OpenUrlCrossRefPubMed
  21. 21.↵
    1. Ardesch JJ,
    2. Buschman HP,
    3. Wagener-Schimmel LJ,
    4. van der Aa HE,
    5. Hageman G.
    Vagus nerve stimulation for medically refractory epilepsy: a long-term follow-up study. Seizure 2007; 16: 579–585.
    OpenUrlCrossRefPubMed
  22. 22.↵
    1. Ardesch JJ,
    2. Sikken JR,
    3. Veltink PH,
    4. van der Aa HE,
    5. Hageman G,
    6. Buschman HP.
    Vagus nerve stimulation for epilepsy activates the vocal folds maximally at therapeutic levels. Epilepsy Res 2010; 89: 227–231.
    OpenUrlPubMed
  23. 23.↵
    1. Dye TJ,
    2. Hantragool S,
    3. Carosella C,
    4. Huang G,
    5. Hossain MM,
    6. Simakajornboon N.
    Sleep disordered breathing in children receiving vagus nerve stimulation therapy. Sleep Med 2021; 79: 101–106.
    OpenUrl
  24. 24.↵
    1. Oh DM,
    2. Johnson J,
    3. Shah B,
    4. Bhat S,
    5. Nuoman R,
    6. Ming X.
    Treatment of vagus nerve stimulator-induced sleep-disordered breathing: A case series. Epilepsy Behav Rep 2019; 12: 100325.
    OpenUrlPubMed
  25. 25.↵
    1. Thompson SL,
    2. O’Leary GH,
    3. Austelle CW,
    4. Gruber E,
    5. Kahn AT,
    6. Manett AJ, et al.
    A Review of Parameter Settings for Invasive and Non-invasive Vagus Nerve Stimulation (VNS) Applied in Neurological and Psychiatric Disorders. Front Neurosci 2021; 15: 709436.
    OpenUrl
  26. 26.↵
    1. DeGiorgio C,
    2. Heck C,
    3. Bunch S,
    4. Britton J,
    5. Green P,
    6. Lancman M, et al.
    Vagus nerve stimulation for epilepsy: randomized comparison of three stimulation paradigms. Neurology 2005; 65: 317–319.
    OpenUrl
  27. 27.↵
    1. Bauer S,
    2. Baier H,
    3. Baumgartner C,
    4. Bohlmann K,
    5. Fauser S,
    6. Graf W, et al.
    Transcutaneous Vagus Nerve Stimulation (tVNS) for Treatment of Drug-Resistant Epilepsy: A Randomized, Double-Blind Clinical Trial (cMPsE02). Brain Stimul 2016; 9: 356–363.
    OpenUrl
  28. 28.↵
    1. Stefan H,
    2. Kreiselmeyer G,
    3. Kerling F,
    4. Kurzbuch K,
    5. Rauch C,
    6. Heers M, et al.
    Transcutaneous vagus nerve stimulation (t-VNS) in pharmacoresistant epilepsies: a proof of concept trial. Epilepsia 2012; 53: e115–e118.
    OpenUrlPubMed
  29. 29.↵
    1. Diener HC,
    2. Goadsby PJ,
    3. Ashina M,
    4. Al-Karagholi MA,
    5. Sinclair A,
    6. Mitsikostas D, et al.
    Non-invasive vagus nerve stimulation (nVNS) for the preventive treatment of episodic migraine: the multicentre, double-blind, randomised, sham-controlled PREMIUM trial. Cephalalgia 2019; 39: 1475–1487.
    OpenUrlCrossRefPubMed
  30. 30.↵
    1. Kinfe TM,
    2. Pintea B,
    3. Muhammad S,
    4. Zaremba S,
    5. Roeske S,
    6. Simon BJ, et al.
    Cervical non-invasive vagus nerve stimulation (nVNS) for preventive and acute treatment of episodic and chronic migraine and migraine-associated sleep disturbance: a prospective observational cohort study. J Headache Pain 2015; 16: 101.
    OpenUrlCrossRefPubMed
Back to top

In this issue

Print
Download PDF
Email Article
Citation Tools
Bookmark this article

Jump to section