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Research ArticleOriginal Article
Open Access

Risk factors for cerebral edema following aneurysm clipping in patients with aneurysmal subarachnoid hemorrhage

Shifeng Xu, Baodong Chen, Hui Qi and Hongbin Liu
Neurosciences Journal April 2024, 29 (2) 90-95; DOI: https://doi.org/10.17712/nsj.2024.2.20230082
Shifeng Xu
From the Department of Neurosurgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China
MBSc
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  • ORCID record for Shifeng Xu
  • For correspondence: [email protected]
Baodong Chen
From the Department of Neurosurgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China
MD
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Hui Qi
From the Department of Neurosurgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China
MM
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Hongbin Liu
From the Department of Neurosurgery, Peking University Shenzhen Hospital, Shenzhen, Guangdong Province, China
MD, medical degree
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    Figure 1

    - Forest plot of clinical characteristics based on multivariate logistic regression analysis.

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    Table 1

    - Results of univariate analysis on cerebral edema following aneurysm clipping [n (%)]

    FactorsComplication group (n=33)Non-complication group (n=199)χ2P
    Gender
    Male18 (54.55)105 (52.76)0.0360.849
    Female15 (45.45)94 (47.24)  
    Age
    ≥50 years17 (51.52)101 (50.75)0.0070.935
    <50 years16 (48.48)98 (49.25)  
    Bleeding frequency
    Once10 (30.30)121 (60.80)10.7130.001
    Recurrent23 (69.70)78 (39.20)  
    Location of aneurysm
    Anterior circulation12 (36.36)127 (63.82)8.8840.003
    Posterior circulation21 (63.64)72 (36.18)  
    Number of aneurysms  
    Single15 (45.45)103 (51.76)0.4500.502
    Multiple18 (54.55)96 (48.24)  
    Aneurysm diameter   
    ≥10 cm17 (51.52)100 (50.25)0.0180.893
    <10 cm16 (48.48)99 (49.75)  
    Fisher grade    
    I-II15 (45.45)142 (71.36)8.6810.003
    III-IV18 (54.55)57 (28.64)  
    WFNS grade    
    I14 (42.42)140 (70.35)9.8920.002
    II19 (57.58)59 (29.65)  
    Hunt-Hess grade    
    I-II10 (30.30)125 (62.81)12.297<0.001
    III-IV23 (69.70)74 (37.19)  
    Hypertension  
    Yes18 (54.55)62 (31.16)6.8540.009
    No15 (45.45)137 (68.84)  
    Diabetes mellitus   
    Yes11 (33.33)42 (21.11)2.4010.121
    No22 (66.67)157 (78.89)  
    Coronary heart disease  
    Yes10 (30.30)40 (20.10)1.7430.187
    No23 (69.70)159 (79.90)  
    Time from onset to surgery  
    ≥12h20 (60.61)70 (35.18)7.7090.005
    <12h13 (39.39)129 (64.82)  
    Hematoma    
    Yes22 (66.67)56 (28.14)18.826<0.001
    No11 (33.33)143 (71.86)  
    • WFNS: World Federation of Neurosurgical Societies.

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    Table 2

    - Results of multivariate logistic regression analysis on cerebral edema following aneurysm clipping.

    VariablesβStandard errorWaldP-valueOdds ratio95% confidence interval
    Recurrent bleeding1.2970.5226.1740.0133.6581.315~10.177
    Location of aneurysm as in the posterior circulation1.3190.4987.0150.0083.7401.409~9.925
    Fisher grade III-IV1.4290.5018.1360.0044.1751.564~11.145
    Hunt grade III-IV1.4280.5486.7900.0094.1701.425~12.208
    WFNS grade II1.5290.42912.7030.0004.6141.990~10.696
    Concomitant hypertension1.2480.4856.6210.0103.4831.346~9.012
    Time from onset to surgery ≥12 h1.3180.4468.7330.0033.7361.559~8.955
    Combined hematoma1.4290.5127.7900.0054.1751.530~11.388
    • WFNS: World Federation of Neurosurgical Societies

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    Table 3

    - Predictive efficiency of combination of risk factors for cerebral edema following aneurysm clipping.

    Risk factorCerebral edemaTotal
    YesNo
    Positive30434
    Negative3195198
    Total33199232
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Neurosciences Journal: 29 (2)
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1 Apr 2024
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Risk factors for cerebral edema following aneurysm clipping in patients with aneurysmal subarachnoid hemorrhage
Shifeng Xu, Baodong Chen, Hui Qi, Hongbin Liu
Neurosciences Journal Apr 2024, 29 (2) 90-95; DOI: 10.17712/nsj.2024.2.20230082

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Risk factors for cerebral edema following aneurysm clipping in patients with aneurysmal subarachnoid hemorrhage
Shifeng Xu, Baodong Chen, Hui Qi, Hongbin Liu
Neurosciences Journal Apr 2024, 29 (2) 90-95; DOI: 10.17712/nsj.2024.2.20230082
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