Neuroprotective effects of all-trans-retinoic acid are mediated via downregulation of TLR4/NF-κB signaling in a rat model of middle cerebral artery occlusion

Lixi Tan; Qian Liu; Songfa Chen; Rongjiao You; Xinyue Li; Tao Wen; Zhongxing Peng

doi:10.17712/nsj.2024.4.20240010

References

1.↵
1. Feigin VL,
2. Brainin M,
3. Norrving B,
4. Martins S,
5. Sacco RL,
6. Hacke W, et al.
World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. Int J Stroke 2022; 17: 18-29.
OpenUrl CrossRef PubMed
2.↵
1. Zhou M,
2. Wang H,
3. Zeng X,
4. Yin P,
5. Zhu J,
6. Chen W, et al.
Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2019; 394: 1145-1158.
OpenUrl CrossRef PubMed
3.↵
1. Ma Q,
2. Li R,
3. Wang L,
4. Yin P,
5. Wang Y,
6. Yan C, et al.
Temporal trend and attributable risk factors of stroke burden in China, 1990-2019: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health 2021; 6: e897-e906.
OpenUrl
4.↵
1. Henderson SJ,
2. Weitz JI,
3. Kim PY
. Fibrinolysis: strategies to enhance the treatment of acute ischemic stroke. J Thromb Haemost 2018; 16: 1932-1940.
OpenUrl
5.↵
1. Zhang JH,
2. Obenaus A,
3. Liebeskind DS,
4. Tang J,
5. Hartman R,
6. Pearce WJ
. Recanalization, reperfusion, and recirculation in stroke. J Cereb Blood Flow Metab 2017; 37: 3818-3823.
OpenUrl
6.↵
1. Qiu Y-M,
2. Zhang C-L,
3. Chen A-Q,
4. Wang H-L,
5. Zhou Y-F,
6. Li Y-N, et al.
Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy? Frontiers In Immunology 2021; 12: 678744.
OpenUrl
7.↵
1. Liu S,
2. Lin F,
3. Wang J,
4. Pan X,
5. Sun L,
6. Wu W
. Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights. Molecules 2022; 27: 4181.
OpenUrl
8.↵
1. Jin R,
2. Yang G,
3. Li G
. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 2010; 87: 779-789.
OpenUrl CrossRef PubMed Web of Science
9.
1. Hu X,
2. Leak RK,
3. Shi Y,
4. Suenaga J,
5. Gao Y,
6. Zheng P, et al.
Microglial and macrophage polarization-new prospects for brain repair. Nat Rev Neurol 2015; 11: 56-64.
OpenUrl CrossRef PubMed
10.↵
1. Han B,
2. Jiang W,
3. Cui P,
4. Zheng K,
5. Dang C,
6. Wang J, et al.
Microglial PGC-1alpha protects against ischemic brain injury by suppressing neuroinflammation. Genome Med 2021; 13: 47.
OpenUrl
11.↵
1. Yang X,
2. Xu S,
3. Qian Y,
4. Xiao Q
. Resveratrol regulates microglia M1/M2 polarization via PGC-1alpha in conditions of neuroinflammatory injury. Brain Behav Immun 2017; 64: 162-172.
OpenUrl
12.↵
1. Tang J,
2. Xu L,
3. Zeng Y,
4. Gong F
. Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway. Int Immunopharmacol 2021; 91: 107272.
OpenUrl
13.↵
1. Duran-Laforet V,
2. Pena-Martinez C,
3. Garcia-Culebras A,
4. Alzamora L,
5. Moro MA,
6. Lizasoain I
. Pathophysiological and pharmacological relevance of TLR4 in peripheral immune cells after stroke. Pharmacol Ther 2021; 228: 107933.
OpenUrl
14.↵
1. Aluri J,
2. Cooper MA,
3. Schuettpelz LG
. Toll-Like Receptor Signaling in the Establishment and Function of the Immune System. Cells 2021; 10: 1374.
OpenUrl CrossRef
15.↵
1. Qian C,
2. Cao X
. Regulation of Toll-like receptor signaling pathways in innate immune responses. Ann N Y Acad Sci 2013; 1283: 67-74.
OpenUrl CrossRef PubMed
16.↵
1. Danzl K,
2. Messner B,
3. Doppler C,
4. Nebert C,
5. Abfalterer A,
6. Sakic A, et al.
Early inhibition of endothelial retinoid uptake upon myocardial infarction restores cardiac function and prevents cell, tissue, and animal death. J Mol Cell Cardiol 2019; 126: 105-117.
OpenUrl
17.
1. Li M,
2. Tian X,
3. An R,
4. Yang M,
5. Zhang Q,
6. Xiang F, et al.
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway. Neurochem Res 2018; 43: 1283-1296.
OpenUrl
18.
1. Barakat M,
2. Hussein AM,
3. Salama MF,
4. Awadalla A,
5. Barakat N,
6. Serria M, et al.
Possible Underlying Mechanisms for the Renoprotective Effect of Retinoic Acid-Pretreated Wharton’s Jelly Mesenchymal Stem Cells against Renal Ischemia/Reperfusion Injury. Cells 2022; 11: 1997.
OpenUrl
19.↵
1. Khedr M,
2. Barakat N,
3. Mohey El-Deen I,
4. Zahran F
. Impact of preconditioning stem cells with all-trans retinoic acid signaling pathway on cisplatin-induced nephrotoxicity by down-regulation of TGFbeta1, IL-6, and caspase-3 and up-regulation of HIF1alpha and VEGF. Saudi J Biol Sci 2022; 29: 831-839.
OpenUrl
20.
1. Sugarman J
. Ethics in the design and conduct of clinical trials. Epidemiol Rev 2002; 24: 54-58.
OpenUrl CrossRef PubMed
21.↵
1. Yang Y,
2. Liu H,
3. Zhang H,
4. Ye Q,
5. Wang J,
6. Yang B, et al.
ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury. J Neurosci 2017; 37: 4692-4704.
OpenUrl Abstract/FREE Full Text
22.↵
1. Li L
. Effect of all-trans retinoic acid on MMP-9 expression after cerebral ischemia-reperfusion injury in rats 2014. From: https://kns.cnki.net/kcms2/article/abstract?v=YK1b_MowDz8_PwCYdv-4oiom8vgP21_6hOlXj_m2MoeppWPz5uCLsIDtkn1-UR5CPltRGaEIOJ7KpQoEmLCOC0x4mH9ir7Qxv8hC1TUzAm1wjIsdvvCoSuQZSw64nGjhGv-58HUV0Z55Mn-jorPmmM2O45bH6f503CZqofDjiGp0nQylBwlVffZwgQESUYC_Upaydnp9tHo=&uniplatform=NZKPT&language=CHS
23.↵
1. Simats A,
2. Liesz A
. Systemic inflammation after stroke: implications for post-stroke comorbidities. EMBO Mol Med 2022; 14: e16269.
OpenUrl
24.↵
1. Wang R,
2. Chen S,
3. Liu Y,
4. Diao S,
5. Xue Y,
6. You X, et al.
All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor kappaB (NFkappaB) signaling. J Biol Chem 2015; 290: 22532-22542.
OpenUrl Abstract/FREE Full Text
25.↵
1. Cai W,
2. Wang J,
3. Hu M,
4. Chen X,
5. Lu Z,
6. Bellanti JA, et al.
All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling. J Neuroinflammation 2019; 16: 175.
OpenUrl
26.↵
1. Li M,
2. Tian X,
3. An R,
4. Yang M,
5. Zhang Q,
6. Xiang F, et al.
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway. Neurochem Res 2018; 43: 1283-1296.
OpenUrl
27.↵
1. Zarei L,
2. Bahrami M,
3. Farhad N,
4. Froushani SMA,
5. Abbasi A
. All-trans retinoic acid effectively reduces atheroma plaque size in a rabbit model of high-fat-induced atherosclerosis. Adv Clin Exp Med 2018; 27: 1631-1636.
OpenUrl
28.↵
1. Cai W,
2. Wang J,
3. Hu M,
4. Chen X,
5. Lu Z,
6. Bellanti JA, et al.
All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling. J Neuroinflammation 2019; 16: 175.
OpenUrl
29.↵
1. Pawluk H,
2. Grześk G,
3. Kołodziejska R,
4. Kozakiewicz M,
5. Woźniak A,
6. Grzechowiak E, et al.
Effect of IL-6 and hsCRP Serum Levels on Functional Prognosis in Stroke Patients Undergoing IV-Thrombolysis: Retrospective Analysis. Clin Interv Aging 2020; 15: 1295-1303.
OpenUrl
30.↵
1. Lambertsen KL,
2. Biber K,
3. Finsen B
. Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab 2012; 32: 1677-1698.
OpenUrl CrossRef PubMed
31.↵
1. Ma Y,
2. Wang J,
3. Wang Y,
4. Yang GY
. The biphasic function of microglia in ischemic stroke. Prog Neurobiol 2017; 157: 247-272.
OpenUrl CrossRef PubMed
32.
1. Fisher FM,
2. Maratos-Flier E
. Understanding the Physiology of FGF21. Annu Rev Physiol 2016; 78: 223-241.
OpenUrl CrossRef PubMed
33.↵
1. Wang J,
2. Xing H,
3. Wan L,
4. Jiang X,
5. Wang C,
6. Wu Y
. Treatment targets for M2 microglia polarization in ischemic stroke. Biomed Pharmacother 2018; 105: 518-525.
OpenUrl CrossRef PubMed
34.↵
1. Wang HY,
2. Hou Y,
3. Sun J,
4. Xu QL,
5. Zhang DQ,
6. Han YC
. Effect of atorvastatin on expression of TLR4 and NF-κB in stroke rats and its protective effect on brain. Eur Rev Med Pharmacol Sci 2020; 24: 10799-10805.
OpenUrl
35.↵
1. Orecchioni M,
2. Ghosheh Y,
3. Pramod AB,
4. Ley K
. Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages. Front Immunol 2019; 10: 1084.
OpenUrl CrossRef PubMed
36.↵
1. Zhou D,
2. Ji L,
3. Chen Y
. TSPO Modulates IL-4-Induced Microglia/Macrophage M2 Polarization via PPAR-γ Pathway. J Mol Neurosci 2020; 70: 542-549.
OpenUrl
37.↵
1. Wang D,
2. Liu F,
3. Zhu L,
4. Lin P,
5. Han F,
6. Wang X, et al.
FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages. J Neuroinflammation 2020; 17: 257.
OpenUrl CrossRef
38.↵
1. Li R,
2. Zhou Y,
3. Zhang S,
4. Li J,
5. Zheng Y,
6. Fan X
. The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-κB pathway exert anti-inflammatory activity in ischemic stroke. Eur J Pharmacol 2022; 914: 174660.
OpenUrl
39.
1. Zhang M,
2. Wang C,
3. Wu J,
4. Ha X,
5. Deng Y,
6. Zhang X, et al.
The Effect and Mechanism of KLF7 in the TLR4/NF-kappaB/IL-6 Inflammatory Signal Pathway of Adipocytes. Mediators Inflamm 2018; 2018: 1756494.
OpenUrl
40.
1. Wu GJ,
2. Lin YW,
3. Chuang CY,
4. Tsai HC,
5. Chen RM
. Liver nitrosation and inflammation in septic rats were suppressed by propofol via downregulating TLR4/NF-kappaB-mediated iNOS and IL-6 gene expressions. Life Sci 2018; 195: 25-32.
OpenUrl
41.↵
1. Gadani SP,
2. Walsh JT,
3. Lukens JR,
4. Kipnis J
. Dealing with Danger in the CNS: The Response of the Immune System to Injury. Neuron 2015; 87: 47-62.
OpenUrl CrossRef PubMed

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[1] 1.↵
Feigin VL,
Brainin M,
Norrving B,
Martins S,
Sacco RL,
Hacke W, et al.
World Stroke Organization (WSO): Global Stroke Fact Sheet 2022. Int J Stroke 2022; 17: 18-29.
OpenUrl CrossRef PubMed

[2] Feigin VL,

[3] Brainin M,

[4] Norrving B,

[5] Martins S,

[6] Sacco RL,

[7] Hacke W, et al.

[8] 2.↵
Zhou M,
Wang H,
Zeng X,
Yin P,
Zhu J,
Chen W, et al.
Mortality, morbidity, and risk factors in China and its provinces, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2019; 394: 1145-1158.
OpenUrl CrossRef PubMed

[9] Zhou M,

[10] Wang H,

[11] Zeng X,

[12] Yin P,

[13] Zhu J,

[14] Chen W, et al.

[15] 3.↵
Ma Q,
Li R,
Wang L,
Yin P,
Wang Y,
Yan C, et al.
Temporal trend and attributable risk factors of stroke burden in China, 1990-2019: an analysis for the Global Burden of Disease Study 2019. Lancet Public Health 2021; 6: e897-e906.
OpenUrl

[16] Ma Q,

[17] Li R,

[18] Wang L,

[19] Yin P,

[20] Wang Y,

[21] Yan C, et al.

[22] 4.↵
Henderson SJ,
Weitz JI,
Kim PY
. Fibrinolysis: strategies to enhance the treatment of acute ischemic stroke. J Thromb Haemost 2018; 16: 1932-1940.
OpenUrl

[23] Henderson SJ,

[24] Weitz JI,

[25] Kim PY

[26] 5.↵
Zhang JH,
Obenaus A,
Liebeskind DS,
Tang J,
Hartman R,
Pearce WJ
. Recanalization, reperfusion, and recirculation in stroke. J Cereb Blood Flow Metab 2017; 37: 3818-3823.
OpenUrl

[27] Zhang JH,

[28] Obenaus A,

[29] Liebeskind DS,

[30] Tang J,

[31] Hartman R,

[32] Pearce WJ

[33] 6.↵
Qiu Y-M,
Zhang C-L,
Chen A-Q,
Wang H-L,
Zhou Y-F,
Li Y-N, et al.
Immune Cells in the BBB Disruption After Acute Ischemic Stroke: Targets for Immune Therapy? Frontiers In Immunology 2021; 12: 678744.
OpenUrl

[34] Qiu Y-M,

[35] Zhang C-L,

[36] Chen A-Q,

[37] Wang H-L,

[38] Zhou Y-F,

[39] Li Y-N, et al.

[40] 7.↵
Liu S,
Lin F,
Wang J,
Pan X,
Sun L,
Wu W
. Polyphenols for the Treatment of Ischemic Stroke: New Applications and Insights. Molecules 2022; 27: 4181.
OpenUrl

[41] Liu S,

[42] Lin F,

[43] Wang J,

[44] Pan X,

[45] Sun L,

[46] Wu W

[47] 8.↵
Jin R,
Yang G,
Li G
. Inflammatory mechanisms in ischemic stroke: role of inflammatory cells. J Leukoc Biol 2010; 87: 779-789.
OpenUrl CrossRef PubMed Web of Science

[48] Jin R,

[49] Yang G,

[50] Li G

[51] 9.
Hu X,
Leak RK,
Shi Y,
Suenaga J,
Gao Y,
Zheng P, et al.
Microglial and macrophage polarization-new prospects for brain repair. Nat Rev Neurol 2015; 11: 56-64.
OpenUrl CrossRef PubMed

[52] Hu X,

[53] Leak RK,

[54] Shi Y,

[55] Suenaga J,

[56] Gao Y,

[57] Zheng P, et al.

[58] 10.↵
Han B,
Jiang W,
Cui P,
Zheng K,
Dang C,
Wang J, et al.
Microglial PGC-1alpha protects against ischemic brain injury by suppressing neuroinflammation. Genome Med 2021; 13: 47.
OpenUrl

[59] Han B,

[60] Jiang W,

[61] Cui P,

[62] Zheng K,

[63] Dang C,

[64] Wang J, et al.

[65] 11.↵
Yang X,
Xu S,
Qian Y,
Xiao Q
. Resveratrol regulates microglia M1/M2 polarization via PGC-1alpha in conditions of neuroinflammatory injury. Brain Behav Immun 2017; 64: 162-172.
OpenUrl

[66] Yang X,

[67] Xu S,

[68] Qian Y,

[69] Xiao Q

[70] 12.↵
Tang J,
Xu L,
Zeng Y,
Gong F
. Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4/NF-kB signaling pathway. Int Immunopharmacol 2021; 91: 107272.
OpenUrl

[71] Tang J,

[72] Xu L,

[73] Zeng Y,

[74] Gong F

[75] 13.↵
Duran-Laforet V,
Pena-Martinez C,
Garcia-Culebras A,
Alzamora L,
Moro MA,
Lizasoain I
. Pathophysiological and pharmacological relevance of TLR4 in peripheral immune cells after stroke. Pharmacol Ther 2021; 228: 107933.
OpenUrl

[76] Duran-Laforet V,

[77] Pena-Martinez C,

[78] Garcia-Culebras A,

[79] Alzamora L,

[80] Moro MA,

[81] Lizasoain I

[82] 14.↵
Aluri J,
Cooper MA,
Schuettpelz LG
. Toll-Like Receptor Signaling in the Establishment and Function of the Immune System. Cells 2021; 10: 1374.
OpenUrl CrossRef

[83] Aluri J,

[84] Cooper MA,

[85] Schuettpelz LG

[86] 15.↵
Qian C,
Cao X
. Regulation of Toll-like receptor signaling pathways in innate immune responses. Ann N Y Acad Sci 2013; 1283: 67-74.
OpenUrl CrossRef PubMed

[87] Qian C,

[88] Cao X

[89] 16.↵
Danzl K,
Messner B,
Doppler C,
Nebert C,
Abfalterer A,
Sakic A, et al.
Early inhibition of endothelial retinoid uptake upon myocardial infarction restores cardiac function and prevents cell, tissue, and animal death. J Mol Cell Cardiol 2019; 126: 105-117.
OpenUrl

[90] Danzl K,

[91] Messner B,

[92] Doppler C,

[93] Nebert C,

[94] Abfalterer A,

[95] Sakic A, et al.

[96] 17.
Li M,
Tian X,
An R,
Yang M,
Zhang Q,
Xiang F, et al.
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway. Neurochem Res 2018; 43: 1283-1296.
OpenUrl

[97] Li M,

[98] Tian X,

[99] An R,

[100] Yang M,

[101] Zhang Q,

[102] Xiang F, et al.

[103] 18.
Barakat M,
Hussein AM,
Salama MF,
Awadalla A,
Barakat N,
Serria M, et al.
Possible Underlying Mechanisms for the Renoprotective Effect of Retinoic Acid-Pretreated Wharton’s Jelly Mesenchymal Stem Cells against Renal Ischemia/Reperfusion Injury. Cells 2022; 11: 1997.
OpenUrl

[104] Barakat M,

[105] Hussein AM,

[106] Salama MF,

[107] Awadalla A,

[108] Barakat N,

[109] Serria M, et al.

[110] 19.↵
Khedr M,
Barakat N,
Mohey El-Deen I,
Zahran F
. Impact of preconditioning stem cells with all-trans retinoic acid signaling pathway on cisplatin-induced nephrotoxicity by down-regulation of TGFbeta1, IL-6, and caspase-3 and up-regulation of HIF1alpha and VEGF. Saudi J Biol Sci 2022; 29: 831-839.
OpenUrl

[111] Khedr M,

[112] Barakat N,

[113] Mohey El-Deen I,

[114] Zahran F

[115] 20.
Sugarman J
. Ethics in the design and conduct of clinical trials. Epidemiol Rev 2002; 24: 54-58.
OpenUrl CrossRef PubMed

[116] Sugarman J

[117] 21.↵
Yang Y,
Liu H,
Zhang H,
Ye Q,
Wang J,
Yang B, et al.
ST2/IL-33-Dependent Microglial Response Limits Acute Ischemic Brain Injury. J Neurosci 2017; 37: 4692-4704.
OpenUrl Abstract/FREE Full Text

[118] Yang Y,

[119] Liu H,

[120] Zhang H,

[121] Ye Q,

[122] Wang J,

[123] Yang B, et al.

[124] 22.↵
Li L
. Effect of all-trans retinoic acid on MMP-9 expression after cerebral ischemia-reperfusion injury in rats 2014. From: https://kns.cnki.net/kcms2/article/abstract?v=YK1b_MowDz8_PwCYdv-4oiom8vgP21_6hOlXj_m2MoeppWPz5uCLsIDtkn1-UR5CPltRGaEIOJ7KpQoEmLCOC0x4mH9ir7Qxv8hC1TUzAm1wjIsdvvCoSuQZSw64nGjhGv-58HUV0Z55Mn-jorPmmM2O45bH6f503CZqofDjiGp0nQylBwlVffZwgQESUYC_Upaydnp9tHo=&uniplatform=NZKPT&language=CHS

[125] Li L

[126] 23.↵
Simats A,
Liesz A
. Systemic inflammation after stroke: implications for post-stroke comorbidities. EMBO Mol Med 2022; 14: e16269.
OpenUrl

[127] Simats A,

[128] Liesz A

[129] 24.↵
Wang R,
Chen S,
Liu Y,
Diao S,
Xue Y,
You X, et al.
All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor kappaB (NFkappaB) signaling. J Biol Chem 2015; 290: 22532-22542.
OpenUrl Abstract/FREE Full Text

[130] Wang R,

[131] Chen S,

[132] Liu Y,

[133] Diao S,

[134] Xue Y,

[135] You X, et al.

[136] 25.↵
Cai W,
Wang J,
Hu M,
Chen X,
Lu Z,
Bellanti JA, et al.
All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling. J Neuroinflammation 2019; 16: 175.
OpenUrl

[137] Cai W,

[138] Wang J,

[139] Hu M,

[140] Chen X,

[141] Lu Z,

[142] Bellanti JA, et al.

[143] 26.↵
Li M,
Tian X,
An R,
Yang M,
Zhang Q,
Xiang F, et al.
All-Trans Retinoic Acid Ameliorates the Early Experimental Cerebral Ischemia-Reperfusion Injury in Rats by Inhibiting the Loss of the Blood-Brain Barrier via the JNK/P38MAPK Signaling Pathway. Neurochem Res 2018; 43: 1283-1296.
OpenUrl

[144] Li M,

[145] Tian X,

[146] An R,

[147] Yang M,

[148] Zhang Q,

[149] Xiang F, et al.

[150] 27.↵
Zarei L,
Bahrami M,
Farhad N,
Froushani SMA,
Abbasi A
. All-trans retinoic acid effectively reduces atheroma plaque size in a rabbit model of high-fat-induced atherosclerosis. Adv Clin Exp Med 2018; 27: 1631-1636.
OpenUrl

[151] Zarei L,

[152] Bahrami M,

[153] Farhad N,

[154] Froushani SMA,

[155] Abbasi A

[156] 28.↵
Cai W,
Wang J,
Hu M,
Chen X,
Lu Z,
Bellanti JA, et al.
All trans-retinoic acid protects against acute ischemic stroke by modulating neutrophil functions through STAT1 signaling. J Neuroinflammation 2019; 16: 175.
OpenUrl

[157] Cai W,

[158] Wang J,

[159] Hu M,

[160] Chen X,

[161] Lu Z,

[162] Bellanti JA, et al.

[163] 29.↵
Pawluk H,
Grześk G,
Kołodziejska R,
Kozakiewicz M,
Woźniak A,
Grzechowiak E, et al.
Effect of IL-6 and hsCRP Serum Levels on Functional Prognosis in Stroke Patients Undergoing IV-Thrombolysis: Retrospective Analysis. Clin Interv Aging 2020; 15: 1295-1303.
OpenUrl

[164] Pawluk H,

[165] Grześk G,

[166] Kołodziejska R,

[167] Kozakiewicz M,

[168] Woźniak A,

[169] Grzechowiak E, et al.

[170] 30.↵
Lambertsen KL,
Biber K,
Finsen B
. Inflammatory cytokines in experimental and human stroke. J Cereb Blood Flow Metab 2012; 32: 1677-1698.
OpenUrl CrossRef PubMed

[171] Lambertsen KL,

[172] Biber K,

[173] Finsen B

[174] 31.↵
Ma Y,
Wang J,
Wang Y,
Yang GY
. The biphasic function of microglia in ischemic stroke. Prog Neurobiol 2017; 157: 247-272.
OpenUrl CrossRef PubMed

[175] Ma Y,

[176] Wang J,

[177] Wang Y,

[178] Yang GY

[179] 32.
Fisher FM,
Maratos-Flier E
. Understanding the Physiology of FGF21. Annu Rev Physiol 2016; 78: 223-241.
OpenUrl CrossRef PubMed

[180] Fisher FM,

[181] Maratos-Flier E

[182] 33.↵
Wang J,
Xing H,
Wan L,
Jiang X,
Wang C,
Wu Y
. Treatment targets for M2 microglia polarization in ischemic stroke. Biomed Pharmacother 2018; 105: 518-525.
OpenUrl CrossRef PubMed

[183] Wang J,

[184] Xing H,

[185] Wan L,

[186] Jiang X,

[187] Wang C,

[188] Wu Y

[189] 34.↵
Wang HY,
Hou Y,
Sun J,
Xu QL,
Zhang DQ,
Han YC
. Effect of atorvastatin on expression of TLR4 and NF-κB in stroke rats and its protective effect on brain. Eur Rev Med Pharmacol Sci 2020; 24: 10799-10805.
OpenUrl

[190] Wang HY,

[191] Hou Y,

[192] Sun J,

[193] Xu QL,

[194] Zhang DQ,

[195] Han YC

[196] 35.↵
Orecchioni M,
Ghosheh Y,
Pramod AB,
Ley K
. Macrophage Polarization: Different Gene Signatures in M1(LPS+) vs. Classically and M2(LPS-) vs. Alternatively Activated Macrophages. Front Immunol 2019; 10: 1084.
OpenUrl CrossRef PubMed

[197] Orecchioni M,

[198] Ghosheh Y,

[199] Pramod AB,

[200] Ley K

[201] 36.↵
Zhou D,
Ji L,
Chen Y
. TSPO Modulates IL-4-Induced Microglia/Macrophage M2 Polarization via PPAR-γ Pathway. J Mol Neurosci 2020; 70: 542-549.
OpenUrl

[202] Zhou D,

[203] Ji L,

[204] Chen Y

[205] 37.↵
Wang D,
Liu F,
Zhu L,
Lin P,
Han F,
Wang X, et al.
FGF21 alleviates neuroinflammation following ischemic stroke by modulating the temporal and spatial dynamics of microglia/macrophages. J Neuroinflammation 2020; 17: 257.
OpenUrl CrossRef

[206] Wang D,

[207] Liu F,

[208] Zhu L,

[209] Lin P,

[210] Han F,

[211] Wang X, et al.

[212] 38.↵
Li R,
Zhou Y,
Zhang S,
Li J,
Zheng Y,
Fan X
. The natural (poly)phenols as modulators of microglia polarization via TLR4/NF-κB pathway exert anti-inflammatory activity in ischemic stroke. Eur J Pharmacol 2022; 914: 174660.
OpenUrl

[213] Li R,

[214] Zhou Y,

[215] Zhang S,

[216] Li J,

[217] Zheng Y,

[218] Fan X

[219] 39.
Zhang M,
Wang C,
Wu J,
Ha X,
Deng Y,
Zhang X, et al.
The Effect and Mechanism of KLF7 in the TLR4/NF-kappaB/IL-6 Inflammatory Signal Pathway of Adipocytes. Mediators Inflamm 2018; 2018: 1756494.
OpenUrl

[220] Zhang M,

[221] Wang C,

[222] Wu J,

[223] Ha X,

[224] Deng Y,

[225] Zhang X, et al.

[226] 40.
Wu GJ,
Lin YW,
Chuang CY,
Tsai HC,
Chen RM
. Liver nitrosation and inflammation in septic rats were suppressed by propofol via downregulating TLR4/NF-kappaB-mediated iNOS and IL-6 gene expressions. Life Sci 2018; 195: 25-32.
OpenUrl

[227] Wu GJ,

[228] Lin YW,

[229] Chuang CY,

[230] Tsai HC,

[231] Chen RM

[232] 41.↵
Gadani SP,
Walsh JT,
Lukens JR,
Kipnis J
. Dealing with Danger in the CNS: The Response of the Immune System to Injury. Neuron 2015; 87: 47-62.
OpenUrl CrossRef PubMed

[233] Gadani SP,

[234] Walsh JT,

[235] Lukens JR,

[236] Kipnis J

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Neuroprotective effects of all-trans-retinoic acid are mediated via downregulation of TLR4/NF-κB signaling in a rat model of middle cerebral artery occlusion

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Neuroprotective effects of all-trans-retinoic acid are mediated via downregulation of TLR4/NF-κB signaling in a rat model of middle cerebral artery occlusion

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