Research ArticleOriginal Article
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Risk factors, clinical characteristics, and outcomes of perinatal stroke in a Tertiary University Hospital

Shaden S. Alfayez, Muddathir H. Hamad, Amal Y. Kentab, Ahmad A. Alanezi, Daniah M. Kurdi, Hanady A. Almuhideb and Fahad A. Bashiri
Neurosciences Journal April 2025, 30 (2) 138-143; DOI: https://doi.org/10.17712/nsj.2025.2.20240089

Article Figures & Data

Tables

  • Table 1

    - Demographics, family history, and pregnancy details of patients with perinatal stroke (N=32).

    CharacteristicsN(%)
    Males15(46.9)
    Females17(53.1)
    Maternal history  
    Hypothyroidism6(18.75)
    Recurrent abortions5(15.63)
    Myasthenia gravis1(3.13)
    COVID-19 infection1(3.13)
    Epilepsy1(3.13)
    Normal23(71.88)
    Family history  
    Seizures7(21.88)
    Stroke1(3.13)
    Haematological diseases1(3.13)
    Congenital heart diseases0(0)
    Renal diseases0(0)
    Metabolic diseases0(0)
    Immunological diseases0(0)
    Liver/GI diseases0(0)
    Consanguinity  
    Consanguineous parents20(62.5)
    Pregnancy  
    Normal28(87.5)
    Abnormal4(12.5)
    Full term29(90.62)
    Preterm3(9.37)

    COVID-19, coronavirus disease 2019; GI, gastrointestinal

    • Table 2

      - Initial stroke symptoms and age at stroke diagnosis (N=32).

      First stroke symptoms:N(%)
      Hemiparesis18(56.25)
      Seizures12(37.5)
      Respiratory distress1(3.13)
      Tiptoe walking1(3.13)
      Age at stroke diagnosis
      At birth6(18.75)
      1–12 months4(12.5)
      13–16 months5(15.62)
      17-23 months0(0)
      2–3 years8(25)
      4–5 years3(6.25)
      Unknown6(18.75)
    • Table 3

      - Details of imaging in patients with perinatal stroke (N=32).

      AssessmentN(%)
      MRA abnormality
      MRA scan8(25)
      MRI/CT scan
      Left MCA13(40.63)
      Right MCA4(12.5)
      Others15(46.88)

      MRA, magnetic resonance angiography; MRI, magnetic resonance imaging; CT, computed tomography; MCA, middle cerebral artery

      • Table 4

        - Diagnosis of epilepsy, age at seizure onset, and assessment of seizure control in patients with perinatal stroke (N=32).

        DiagnosisN(%)
        Epilepsy22(68.75)
        Age at onset of seizures  
        Birth4(18.18)
        1–6 months7(31.81)
        7 months to 2 years6(27.27)
        3–10 years5(22.72)
        Seizures assessment  
        Seizure-free (ASMs discontinued)5(22.72)
        Controlled seizures (receiving ASMs)11(50)
        Partially controlled seizures3(13.63)
        Uncontrolled seizures2(9.09)
        Unknown1(3.13)

        ASMs - anti-seizure medications

        • Table 5

          - IQ assessment results in patients with perinatal stroke (N=12).

          IQ assessmentN(%)
          High average (110–119)1(3.13)
          Average (90–109)3(9.37)
          Low average (80–89)1(3.13)
          Borderline impairment (70–79)5(15.63)
          Moderately impaired (40–54)1(3.13)
          Severely impaired (<40)1(3.13)

          IQ - intelligence quotient

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