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Research ArticleOriginal Article
Open Access

Pre-training Catechin gavage prevents memory impairment induced by intracerebroventricular streptozotocin in rats

Marzieh Zamani, Kambiz Rohampour, Maryam Zeraati, Narges Hosseinmardi and Mostafa M. Kazemian
Neurosciences Journal July 2015, 20 (3) 225-229; DOI: https://doi.org/10.17712/nsj.2015.3.20140440
Marzieh Zamani
From the Cellular and Molecular Research Center (Zamani, Rohampour, Kazemian), Qom University of Medical Sciences, Qom, Department of Physiology and Pharmacology (Zeraati), Faculty of Medicine, Alborz University of Medical Sciences, Karaj, and the Department of Physiology (Hosseinmardi), Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Kambiz Rohampour
From the Cellular and Molecular Research Center (Zamani, Rohampour, Kazemian), Qom University of Medical Sciences, Qom, Department of Physiology and Pharmacology (Zeraati), Faculty of Medicine, Alborz University of Medical Sciences, Karaj, and the Department of Physiology (Hosseinmardi), Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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  • For correspondence: [email protected]
Maryam Zeraati
From the Cellular and Molecular Research Center (Zamani, Rohampour, Kazemian), Qom University of Medical Sciences, Qom, Department of Physiology and Pharmacology (Zeraati), Faculty of Medicine, Alborz University of Medical Sciences, Karaj, and the Department of Physiology (Hosseinmardi), Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Narges Hosseinmardi
From the Cellular and Molecular Research Center (Zamani, Rohampour, Kazemian), Qom University of Medical Sciences, Qom, Department of Physiology and Pharmacology (Zeraati), Faculty of Medicine, Alborz University of Medical Sciences, Karaj, and the Department of Physiology (Hosseinmardi), Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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Mostafa M. Kazemian
From the Cellular and Molecular Research Center (Zamani, Rohampour, Kazemian), Qom University of Medical Sciences, Qom, Department of Physiology and Pharmacology (Zeraati), Faculty of Medicine, Alborz University of Medical Sciences, Karaj, and the Department of Physiology (Hosseinmardi), Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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    Figure 1

    Effects of STZ treatment and pre-training CAT gavage on STL during acquisition phase on the training day A) and on the number of trials to acquisition B). Values are expressed as mean±SEM. *p=0.041 versus Sham and #p=0.027 versus STZ. (n=6, ANOVA multiple group comparison, LSD’s post hoc). STL - Step-through latencies, STZ - streptozotocin treated group, Sham - saline treated, CAT - catechin gavage, and STZ+CAT- streptozotocin treated with catechin gavage, SEM - standard error of the mean, ANOVA - analysis of variance, LSD - least significant difference.

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    Figure 2

    Passive avoidance early and late retrieval as time spent in the dark compartment (TDC) on day one A), and day 7 B) after training. The TDC is indicated in seconds, as mean±SEM. **p=0.009, ***p=0.000 versus sham and #p=0.031, #p=0.006 versus STZ (n=6, ANOVA, post hoc: LSD). STZ - streptozotocin treated group, Sham - saline treated, CAT - Catechin gavage, and STZ+CAT - streptozotocin treated with catechin gavage SEM - standard error of the mean, ANOVA - analysis of variance, LSD - least significant difference.

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Neurosciences Journal: 20 (3)
Neurosciences Journal
Vol. 20, Issue 3
1 Jul 2015
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Pre-training Catechin gavage prevents memory impairment induced by intracerebroventricular streptozotocin in rats
Marzieh Zamani, Kambiz Rohampour, Maryam Zeraati, Narges Hosseinmardi, Mostafa M. Kazemian
Neurosciences Journal Jul 2015, 20 (3) 225-229; DOI: 10.17712/nsj.2015.3.20140440

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Pre-training Catechin gavage prevents memory impairment induced by intracerebroventricular streptozotocin in rats
Marzieh Zamani, Kambiz Rohampour, Maryam Zeraati, Narges Hosseinmardi, Mostafa M. Kazemian
Neurosciences Journal Jul 2015, 20 (3) 225-229; DOI: 10.17712/nsj.2015.3.20140440
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