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Case ReportCase Report
Open Access

A rare case of autoimmune limbic encephalitis: an uncharted territory!

Hatim Ibrahim, Abdulelah N. Al Jasser, Sonia A. Khan and Kalthoum G. Tlili
Neurosciences Journal October 2017, 22 (4) 292-297; DOI: https://doi.org/10.17712/nsj.2017.4.20170150
Hatim Ibrahim
From the Department of Neurology (Khan, Ibrahim), Department of Radiology (Tlili), Prince Sultan Military Medical City, and from the Faculty of Medicine (Aljasser), King Saud University, Riyadh, Kingdom of Saudi Arabia
MD
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Abdulelah N. Al Jasser
From the Department of Neurology (Khan, Ibrahim), Department of Radiology (Tlili), Prince Sultan Military Medical City, and from the Faculty of Medicine (Aljasser), King Saud University, Riyadh, Kingdom of Saudi Arabia
MD
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Sonia A. Khan
From the Department of Neurology (Khan, Ibrahim), Department of Radiology (Tlili), Prince Sultan Military Medical City, and from the Faculty of Medicine (Aljasser), King Saud University, Riyadh, Kingdom of Saudi Arabia
MD, FRCP (Edin)
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  • For correspondence: [email protected]
Kalthoum G. Tlili
From the Department of Neurology (Khan, Ibrahim), Department of Radiology (Tlili), Prince Sultan Military Medical City, and from the Faculty of Medicine (Aljasser), King Saud University, Riyadh, Kingdom of Saudi Arabia
MD, FBR
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    Figure 1

    EEG features a) Interictal EEG showed normal EEG background of 8-9 hertz bilaterally (thin arrows). Intermixed slow transients of 6-7 hertz in the temporal regions bilaterally (thick arrows). No epileptiform discharges seen, b) The ictal EEG showed periods of right hemispheric electro-decremental response with right hemispheric alpha frequency attenuation at FP2, F4, T2, T4, T6, P4 & O2 with some diffusion to the left for 4 seconds time locked with left facio brachial tonic seizure (thick arrows) followed by recovery of the EEG background intermixed with right temporal slow transients of 4-5 hertz at T2, T4 and T6 (thin arrows).

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    Figure 2

    MRI brain at presentation a) Axial apparent diffusion coefficient (ADC) map, b) Axial fluid attenuated inversion recovery (FLAIR) and c) Coronal T2 spin echo (T2SE) images showing abnormal high T2 and FLAIR signal intensity and swelling with blurring of the margins of right amygdala and medial right temporal lobe cortex and increased diffusivity associated on ADC map (White arrows). No abnormal enhancement (post contrast images not shown).

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    Figure 3

    PET scan of the brain at presentation showed hypermetabolic right mesial temporal area (White & black arrow heads) which matched with MRI abnormality (White arrow).

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    Figure 4

    Neuroimaging at 7 months of treatment a) MRI brain axial ADC map, b) MRI brain axial FLAIR and c) MRI brain coronal T2SE showing almost complete resolution of the signal abnormality with no atrophic changes (white arrows). d-e) The PET scan of the brain showed interval resolution of the focal hypermetabolic activity previously seen in the right temporal lobe with ipsilateral relative mesial temporal and right basal ganglia hypometabolism (white arrows).

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Neurosciences Journal: 22 (4)
Neurosciences Journal
Vol. 22, Issue 4
1 Oct 2017
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A rare case of autoimmune limbic encephalitis: an uncharted territory!
Hatim Ibrahim, Abdulelah N. Al Jasser, Sonia A. Khan, Kalthoum G. Tlili
Neurosciences Journal Oct 2017, 22 (4) 292-297; DOI: 10.17712/nsj.2017.4.20170150

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A rare case of autoimmune limbic encephalitis: an uncharted territory!
Hatim Ibrahim, Abdulelah N. Al Jasser, Sonia A. Khan, Kalthoum G. Tlili
Neurosciences Journal Oct 2017, 22 (4) 292-297; DOI: 10.17712/nsj.2017.4.20170150
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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