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Research ArticleOriginal Article
Open Access

Inflammatory bowel disease and restless leg syndrome

Mahmoud H. Mosli, Lujain M. Bukhari, Alya A. Khoja, Nuha A. Ashour, Hadeel R. Aljahdali, Ohood A. Khoja, Faris F. Alhejaili and Omar I. Saadah
Neurosciences Journal August 2020, 25 (4) 301-307; DOI: https://doi.org/10.17712/nsj.2020.4.20200021
Mahmoud H. Mosli
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS, MSc
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Lujain M. Bukhari
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Alya A. Khoja
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Nuha A. Ashour
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Hadeel R. Aljahdali
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Ohood A. Khoja
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS
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Faris F. Alhejaili
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS, MSc
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Omar I. Saadah
From the Department of Medicine (Mosli, Bukhari, Khoja A, Ashour, Aljahdali, Khoja O, Alhejaili), Inflammatory Bowel Disease Research Group (Mosli, Saadah), Sleep Medicine and Research Center (SMRC) (Alhejaili) and from the Department of Pediatrics (Saadah), Faculty of Medicine, King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
MBBS, MRCP
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Abstract

Objectives: Inflammatory bowel disease (IBD) has been associated with restless leg syndrome (RLS). This study aims to explore the prevalence, clinical predictors, and severity of RLS in IBD patients compared to controls.

Methods: We conducted a case-control study between January and December of 2019 comparing IBD patients with controls. Assessment of RLS was performed using the previously validated diagnostic restless leg syndrome questionnaire (RLSQ). Logistic regression analyses were applied to investigate associations between patient demographics and clinical features and RLS diagnosis.

Results: A total of 218 IBD patients and 211 healthy controls were incorporated after excluding 6 patients with positional discomfort and 4 patients with habitual foot tapping. The mean age was 30.2±11.7 and 64% were females. The prevalence of RLS was 16/218 (7.34%) and 17/211 (8.06%) among cases and controls, respectively. Based on the RLSQ severity score, 6/16 (37.5%), 4/16 (25%) and 1/16 (6.3%) of the IBD patients with RLS had mild, moderate and severe RLS; respectively. The odds of IBD were lower among patients with confirmed RLS (OR=0.90, 95% CI=0.44-1.84, p = 0.78). In the logistic regression analysis, only vitamin B12 deficiency (OR=10.20, 95% CI=1.40-74.10, p = 0.022) was associated with RLS diagnosis among IBD patients.

Conclusion: No difference was found in the prevalence of RLS between IBD patients and non-IBD controls. Vitamin B12 deficiency was associated with RLS diagnosis among patients with IBD.

Footnotes

  • Disclosure. Authors have no conflict of interests, and the work was not supported or funded by any drug company.

  • Received February 21, 2020.
  • Accepted May 4, 2020.
  • Copyright: © Neurosciences

Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work.

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Inflammatory bowel disease and restless leg syndrome
Mahmoud H. Mosli, Lujain M. Bukhari, Alya A. Khoja, Nuha A. Ashour, Hadeel R. Aljahdali, Ohood A. Khoja, Faris F. Alhejaili, Omar I. Saadah
Neurosciences Journal Aug 2020, 25 (4) 301-307; DOI: 10.17712/nsj.2020.4.20200021

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Inflammatory bowel disease and restless leg syndrome
Mahmoud H. Mosli, Lujain M. Bukhari, Alya A. Khoja, Nuha A. Ashour, Hadeel R. Aljahdali, Ohood A. Khoja, Faris F. Alhejaili, Omar I. Saadah
Neurosciences Journal Aug 2020, 25 (4) 301-307; DOI: 10.17712/nsj.2020.4.20200021
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© 2025 Neurosciences Journal Neurosciences is copyright under the Berne Convention and the International Copyright Convention. All rights reserved. Neurosciences is an Open Access journal and articles published are distributed under the terms of the Creative Commons Attribution-NonCommercial License (CC BY-NC). Readers may copy, distribute, and display the work for non-commercial purposes with the proper citation of the original work. Electronic ISSN 1658-3183. Print ISSN 1319-6138.

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