Research ArticleOriginal Article
Open Access

The clinicopathological features and prognosis of multifocal high-grade gliomas in adults with H3F3A mutation

Yongrui Zhao, Yidong Chen, Leiming Wang, Ying Gao and Jiankun Xu
Neurosciences Journal January 2023, 28 (1) 42-47; DOI: https://doi.org/10.17712/nsj.2023.1.20220080

Article Figures & Data

Figures

  • Figure 1
    Figure 1

    - Radiographic features of case 1. Contrast-enhanced MRI shows 2 lesions in the right frontal-temporal (A) and right parietal lobes (B).

  • Figure 2
    Figure 2

    - Radiographic features of case 2. T1-weighted image shows 2 lesions located in the right basal ganglia and right thalamus (A), with obvious inhomogeneous enhancement on enhanced scans (B).

  • Figure 3
    Figure 3

    - Radiographic features of case 3. The lesion was unevenly enhanced on contrast-enhanced MRI. The FLAIR image shows multiple lesions in the left frontal lobe, bilateral thalamus (A), and right frontal lobe (B), and the lesions are not enhanced (C).

  • Figure 4
    Figure 4

    - Radiographic features of case 4. The T2-weighted image shows that the lesion was located in the right basal ganglia, involving the thalamus (A), and the FLAIR image shows that another lesion was located in the right temporal lobe (B). Contrast-enhanced MRI shows that the lesion was enhanced in the right basal ganglia (C).

  • Figure 5
    Figure 5

    - Kaplan–Meier survival curve. Kaplan–Meier survival curves and log-rank tests for PFS (A) and OS (B). The median PFS and OS were 9.5 months and 14.5 months, respectively, in M-HGGs patients with H3F3A mutations. For non-H3F3A-mutated M-HGGs patients, the median PFS and OS were 7.0 months and 18.0 months, respectively. Comparisons between the 2 groups using the log-rank test indicated no significant difference.

Tables

  • Table 1

    - Characteristics of 4 patients with H3F3A-mutant M-HGGs.

    No.Age (y)SexHisto-diagnosisNo. of lesionsLocationH3F3AIDHTERTMGMTTreatmentPFS (mo.)OS (mo.)
    127FGBM2FL+TL+PL, RH3G34RwtwtmetSTR+RT(66Gy)+TMZ1316
    265FHGG2BG+TH, RH3K27 MwtwtmetBiopsy+RT(60Gy)+TMZ1114
    337MAA3FL+TH, BH3K27 MwtwtunmetBiopsy+RT(54Gy)815
    435MHGG2TL+BG+TH, RH3K27 MwtwtunmetBiopsy+RT(60Gy)+TTF67

    M - male; F - female; GBM - glioblastoma; HGG - high-grade glioma; AA - anaplastic astrocytoma; FL - frontal lobe; PL - parietal lobe; TH - thalamus; TL - temporal lobe; BG - basal ganglia; R - right; L - left; B - bilateral; wt - wild-type; met - methylated; unme t- unmethylated; STR - subtotal resection; RT - radiotherapy; TMZ - temozolomide; TTF - tumor-treating fields; mo - month(s)

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